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Superenhancer reprogramming drives a B-cell-epithelial transition and high-risk leukemia.
Hu Y, Zhang Z, Kashiwagi M, Yoshida T, Joshi I, Jena N, Somasundaram R, Emmanuel AO, Sigvardsson M, Fitamant J, El-Bardeesy N, Gounari F, Van Etten RA, Georgopoulos K. Hu Y, et al. Among authors: sigvardsson m. Genes Dev. 2016 Sep 1;30(17):1971-90. doi: 10.1101/gad.283762.116. Genes Dev. 2016. PMID: 27664237 Free PMC article.
Ebf1 heterozygosity results in increased DNA damage in pro-B cells and their synergistic transformation by Pax5 haploinsufficiency.
Prasad MA, Ungerbäck J, Åhsberg J, Somasundaram R, Strid T, Larsson M, Månsson R, De Paepe A, Lilljebjörn H, Fioretos T, Hagman J, Sigvardsson M. Prasad MA, et al. Among authors: sigvardsson m. Blood. 2015 Jun 25;125(26):4052-9. doi: 10.1182/blood-2014-12-617282. Epub 2015 Apr 2. Blood. 2015. PMID: 25838350 Free PMC article.
Cellular plasticity in B-cell leukemia.
Somasundaram R, Strid T, Sigvardsson M. Somasundaram R, et al. Among authors: sigvardsson m. Cell Cycle. 2017 Mar 19;16(6):495-496. doi: 10.1080/15384101.2017.1285635. Epub 2017 Jan 24. Cell Cycle. 2017. PMID: 28118066 Free PMC article. No abstract available.
Dissection of progenitor compartments resolves developmental trajectories in B-lymphopoiesis.
Jensen CT, Åhsberg J, Sommarin MNE, Strid T, Somasundaram R, Okuyama K, Ungerbäck J, Kupari J, Airaksinen MS, Lang S, Bryder D, Soneji S, Karlsson G, Sigvardsson M. Jensen CT, et al. Among authors: sigvardsson m. J Exp Med. 2018 Jul 2;215(7):1947-1963. doi: 10.1084/jem.20171384. Epub 2018 Jun 13. J Exp Med. 2018. PMID: 29899037 Free PMC article.
PAX5 is part of a functional transcription factor network targeted in lymphoid leukemia.
Okuyama K, Strid T, Kuruvilla J, Somasundaram R, Cristobal S, Smith E, Prasad M, Fioretos T, Lilljebjörn H, Soneji S, Lang S, Ungerbäck J, Sigvardsson M. Okuyama K, et al. Among authors: sigvardsson m. PLoS Genet. 2019 Aug 5;15(8):e1008280. doi: 10.1371/journal.pgen.1008280. eCollection 2019 Aug. PLoS Genet. 2019. PMID: 31381561 Free PMC article.
150 results