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Superenhancer reprogramming drives a B-cell-epithelial transition and high-risk leukemia.
Hu Y, Zhang Z, Kashiwagi M, Yoshida T, Joshi I, Jena N, Somasundaram R, Emmanuel AO, Sigvardsson M, Fitamant J, El-Bardeesy N, Gounari F, Van Etten RA, Georgopoulos K. Hu Y, et al. Among authors: gounari f. Genes Dev. 2016 Sep 1;30(17):1971-90. doi: 10.1101/gad.283762.116. Genes Dev. 2016. PMID: 27664237 Free PMC article.
Chromatin restriction by the nucleosome remodeler Mi-2β and functional interplay with lineage-specific transcription regulators control B-cell differentiation.
Yoshida T, Hu Y, Zhang Z, Emmanuel AO, Galani K, Muhire B, Snippert HJ, Williams CJ, Tolstorukov MY, Gounari F, Georgopoulos K. Yoshida T, et al. Among authors: gounari f. Genes Dev. 2019 Jul 1;33(13-14):763-781. doi: 10.1101/gad.321901.118. Epub 2019 May 23. Genes Dev. 2019. PMID: 31123064 Free PMC article.
Transcriptional regulation of the Ikzf1 locus.
Yoshida T, Landhuis E, Dose M, Hazan I, Zhang J, Naito T, Jackson AF, Wu J, Perotti EA, Kaufmann C, Gounari F, Morgan BA, Georgopoulos K. Yoshida T, et al. Among authors: gounari f. Blood. 2013 Oct 31;122(18):3149-59. doi: 10.1182/blood-2013-01-474916. Epub 2013 Sep 3. Blood. 2013. PMID: 24002445 Free PMC article.
β-Catenin induces T-cell transformation by promoting genomic instability.
Dose M, Emmanuel AO, Chaumeil J, Zhang J, Sun T, Germar K, Aghajani K, Davis EM, Keerthivasan S, Bredemeyer AL, Sleckman BP, Rosen ST, Skok JA, Le Beau MM, Georgopoulos K, Gounari F. Dose M, et al. Among authors: gounari f. Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):391-6. doi: 10.1073/pnas.1315752111. Epub 2013 Dec 26. Proc Natl Acad Sci U S A. 2014. PMID: 24371308 Free PMC article.
β-Catenin promotes colitis and colon cancer through imprinting of proinflammatory properties in T cells.
Keerthivasan S, Aghajani K, Dose M, Molinero L, Khan MW, Venkateswaran V, Weber C, Emmanuel AO, Sun T, Bentrem DJ, Mulcahy M, Keshavarzian A, Ramos EM, Blatner N, Khazaie K, Gounari F. Keerthivasan S, et al. Among authors: gounari f. Sci Transl Med. 2014 Feb 26;6(225):225ra28. doi: 10.1126/scitranslmed.3007607. Sci Transl Med. 2014. PMID: 24574339 Free PMC article.
Wnt-β-catenin activation epigenetically reprograms Treg cells in inflammatory bowel disease and dysplastic progression.
Quandt J, Arnovitz S, Haghi L, Woehlk J, Mohsin A, Okoreeh M, Mathur PS, Emmanuel AO, Osman A, Krishnan M, Morin SB, Pearson AT, Sweis RF, Pekow J, Weber CR, Khazaie K, Gounari F. Quandt J, et al. Among authors: gounari f. Nat Immunol. 2021 Apr;22(4):471-484. doi: 10.1038/s41590-021-00889-2. Epub 2021 Mar 4. Nat Immunol. 2021. PMID: 33664518 Free PMC article.
CDK6 kinase activity is required for thymocyte development.
Hu MG, Deshpande A, Schlichting N, Hinds EA, Mao C, Dose M, Hu GF, Van Etten RA, Gounari F, Hinds PW. Hu MG, et al. Among authors: gounari f. Blood. 2011 Jun 9;117(23):6120-31. doi: 10.1182/blood-2010-08-300517. Epub 2011 Apr 20. Blood. 2011. PMID: 21508411 Free PMC article.
79 results