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A new synthetic varacin analogue, 8-(trifluoromethyl)-1,2,3,4,5-benzopentathiepin-6-amine hydrochloride (TC-2153), decreased hereditary catalepsy and increased the BDNF gene expression in the hippocampus in mice.
Kulikov AV, Tikhonova MA, Kulikova EA, Volcho KP, Khomenko TM, Salakhutdinov NF, Popova NK. Kulikov AV, et al. Psychopharmacology (Berl). 2012 Jun;221(3):469-78. doi: 10.1007/s00213-011-2594-8. Epub 2011 Nov 30. Psychopharmacology (Berl). 2012. PMID: 22127556
Synthesis and biological evaluation of novel tyrosyl-DNA phosphodiesterase 1 inhibitors with a benzopentathiepine moiety.
Zakharenko A, Khomenko T, Zhukova S, Koval O, Zakharova O, Anarbaev R, Lebedeva N, Korchagina D, Komarova N, Vasiliev V, Reynisson J, Volcho K, Salakhutdinov N, Lavrik O. Zakharenko A, et al. Among authors: khomenko t. Bioorg Med Chem. 2015 May 1;23(9):2044-52. doi: 10.1016/j.bmc.2015.03.020. Epub 2015 Mar 12. Bioorg Med Chem. 2015. PMID: 25819333
Anti-influenza activity of monoterpene-containing substituted coumarins.
Khomenko TM, Zarubaev VV, Orshanskaya IR, Kadyrova RA, Sannikova VA, Korchagina DV, Volcho KP, Salakhutdinov NF. Khomenko TM, et al. Bioorg Med Chem Lett. 2017 Jul 1;27(13):2920-2925. doi: 10.1016/j.bmcl.2017.04.091. Epub 2017 Apr 29. Bioorg Med Chem Lett. 2017. PMID: 28501512
Inhibitor of Striatal-Enriched Protein Tyrosine Phosphatase, 8-(Trifluoromethyl)-1,2,3,4,5-Benzopentathiepin-6-Amine hydrochloride (TC-2153), Produces Antidepressant-Like Effect and Decreases Functional Activity and Protein Level of 5-HT2A Receptor in the Brain.
Kulikova EA, Khotskin NV, Illarionova NB, Sorokin IE, Bazhenova EY, Kondaurova EM, Volcho KP, Khomenko TM, Salakhutdinov NF, Ponimaskin E, Naumenko VS, Kulikov AV. Kulikova EA, et al. Among authors: khomenko tm. Neuroscience. 2018 Dec 1;394:220-231. doi: 10.1016/j.neuroscience.2018.10.031. Epub 2018 Oct 24. Neuroscience. 2018. PMID: 30367948
Antimicrobial Activity of Substituted Benzopentathiepin-6-amines.
Khomenko TM, Korchagina DV, Baev DS, Vassiliev PM, Volcho KP, Salakhutdinov NF. Khomenko TM, et al. J Antibiot (Tokyo). 2019 Aug;72(8):590-599. doi: 10.1038/s41429-019-0191-y. Epub 2019 May 22. J Antibiot (Tokyo). 2019. PMID: 31118480
Promising New Inhibitors of Tyrosyl-DNA Phosphodiesterase I (Tdp 1) Combining 4-Arylcoumarin and Monoterpenoid Moieties as Components of Complex Antitumor Therapy.
Khomenko TM, Zakharenko AL, Chepanova AA, Ilina ES, Zakharova OD, Kaledin VI, Nikolin VP, Popova NA, Korchagina DV, Reynisson J, Chand R, Ayine-Tora DM, Patel J, Leung IKH, Volcho KP, Salakhutdinov NF, Lavrik OI. Khomenko TM, et al. Int J Mol Sci. 2019 Dec 23;21(1):126. doi: 10.3390/ijms21010126. Int J Mol Sci. 2019. PMID: 31878088 Free PMC article.
New type of anti-influenza agents based on benzo[d][1,3]dithiol core.
Khomenko TM, Zarubaev VV, Kireeva MV, Volobueva AS, Slita AV, Borisevich SS, Korchagina DV, Komarova NI, Volcho KP, Salakhutdinov NF. Khomenko TM, et al. Bioorg Med Chem Lett. 2020 Dec 15;30(24):127653. doi: 10.1016/j.bmcl.2020.127653. Epub 2020 Oct 28. Bioorg Med Chem Lett. 2020. PMID: 33129992
63 results