Aspirin inhibits the production of proangiogenic 15(S)-HETE by platelet cyclooxygenase-1.
Rauzi F, Kirkby NS, Edin ML, Whiteford J, Zeldin DC, Mitchell JA, Warner TD.
Rauzi F, et al. Among authors: whiteford j.
FASEB J. 2016 Dec;30(12):4256-4266. doi: 10.1096/fj.201600530R. Epub 2016 Sep 15.
FASEB J. 2016.
PMID: 27633788
Free PMC article.
Thus, 15(S)-HETE represents a potential target for the development of novel antiangiogenic therapeutics, and blockade of its production may provide a mechanism for the anticancer effects of aspirin.-Rauzi, F., Kirkby, N. S., Edin, M. L., Whiteford, J. Zeldin, D. C., …
Thus, 15(S)-HETE represents a potential target for the development of novel antiangiogenic therapeutics, and blockade of its production may …