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Aspirin inhibits the production of proangiogenic 15(S)-HETE by platelet cyclooxygenase-1.
Rauzi F, Kirkby NS, Edin ML, Whiteford J, Zeldin DC, Mitchell JA, Warner TD. Rauzi F, et al. Among authors: whiteford j. FASEB J. 2016 Dec;30(12):4256-4266. doi: 10.1096/fj.201600530R. Epub 2016 Sep 15. FASEB J. 2016. PMID: 27633788 Free PMC article.
Thus, 15(S)-HETE represents a potential target for the development of novel antiangiogenic therapeutics, and blockade of its production may provide a mechanism for the anticancer effects of aspirin.-Rauzi, F., Kirkby, N. S., Edin, M. L., Whiteford, J. Zeldin, D. C., …
Thus, 15(S)-HETE represents a potential target for the development of novel antiangiogenic therapeutics, and blockade of its production may …
Shed syndecan-2 inhibits angiogenesis.
De Rossi G, Evans AR, Kay E, Woodfin A, McKay TR, Nourshargh S, Whiteford JR. De Rossi G, et al. J Cell Sci. 2014 Nov 1;127(Pt 21):4788-99. doi: 10.1242/jcs.153015. J Cell Sci. 2014. PMID: 25179601 Free PMC article.
Interleukin-6 Stimulates Defective Angiogenesis.
Gopinathan G, Milagre C, Pearce OM, Reynolds LE, Hodivala-Dilke K, Leinster DA, Zhong H, Hollingsworth RE, Thompson R, Whiteford JR, Balkwill F. Gopinathan G, et al. Cancer Res. 2015 Aug 1;75(15):3098-107. doi: 10.1158/0008-5472.CAN-15-1227. Epub 2015 Jun 16. Cancer Res. 2015. PMID: 26081809 Free PMC article.
Syndecan-3 in Inflammation and Angiogenesis.
Arokiasamy S, Balderstone MJM, De Rossi G, Whiteford JR. Arokiasamy S, et al. Among authors: whiteford jr. Front Immunol. 2020 Jan 9;10:3031. doi: 10.3389/fimmu.2019.03031. eCollection 2019. Front Immunol. 2020. PMID: 31998313 Free PMC article. Review.
Pathological Angiogenesis Requires Syndecan-4 for Efficient VEGFA-Induced VE-Cadherin Internalization.
De Rossi G, Vähätupa M, Cristante E, Arokiasamy S, Liyanage SE, May U, Pellinen L, Uusitalo-Järvinen H, Bainbridge JW, Järvinen TAH, Whiteford JR. De Rossi G, et al. Among authors: whiteford jr. Arterioscler Thromb Vasc Biol. 2021 Apr;41(4):1374-1389. doi: 10.1161/ATVBAHA.121.315941. Epub 2021 Feb 18. Arterioscler Thromb Vasc Biol. 2021. PMID: 33596666 Free PMC article.
67 results