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Pharmacokinetic Modeling of Paracetamol Uptake and Clearance in Zebrafish Larvae: Expanding the Allometric Scale in Vertebrates with Five Orders of Magnitude.
Kantae V, Krekels EH, Ordas A, González O, van Wijk RC, Harms AC, Racz PI, van der Graaf PH, Spaink HP, Hankemeier T. Kantae V, et al. Among authors: van der graaf ph, van wijk rc. Zebrafish. 2016 Dec;13(6):504-510. doi: 10.1089/zeb.2016.1313. Epub 2016 Sep 15. Zebrafish. 2016. PMID: 27632065 Free PMC article.
Towards personalized treatment of pain using a quantitative systems pharmacology approach.
Goulooze SC, Krekels EHJ, van Dijk M, Tibboel D, van der Graaf PH, Hankemeier T, Knibbe CAJ, van Hasselt JGC. Goulooze SC, et al. Among authors: van der graaf ph, van dijk m, van hasselt jgc. Eur J Pharm Sci. 2017 Nov 15;109S:S32-S38. doi: 10.1016/j.ejps.2017.05.027. Epub 2017 May 12. Eur J Pharm Sci. 2017. PMID: 28506867 Free article. Review.
Drugs Being Eliminated via the Same Pathway Will Not Always Require Similar Pediatric Dose Adjustments.
Calvier EAM, Krekels EHJ, Yu H, Välitalo PAJ, Johnson TN, Rostami-Hodjegan A, Tibboel D, van der Graaf PH, Danhof M, Knibbe CAJ. Calvier EAM, et al. Among authors: van der graaf ph. CPT Pharmacometrics Syst Pharmacol. 2018 Mar;7(3):175-185. doi: 10.1002/psp4.12273. Epub 2018 Feb 5. CPT Pharmacometrics Syst Pharmacol. 2018. PMID: 29399979 Free PMC article.
Blood-Based Biomarkers of Quinpirole Pharmacology: Cluster-Based PK/PD and Metabolomics to Unravel the Underlying Dynamics in Rat Plasma and Brain.
van den Brink WJ, Hartman R, van den Berg DJ, Flik G, Gonzalez-Amoros B, Koopman N, Elassais-Schaap J, van der Graaf PH, Hankemeier T, de Lange ECM. van den Brink WJ, et al. Among authors: van der graaf ph, van den berg dj. CPT Pharmacometrics Syst Pharmacol. 2019 Feb;8(2):107-117. doi: 10.1002/psp4.12370. Epub 2019 Jan 24. CPT Pharmacometrics Syst Pharmacol. 2019. PMID: 30680960 Free PMC article.
Children Are Not Small Adults, but Can We Treat Them As Such?
Krekels EHJ, Calvier EAM, van der Graaf PH, Knibbe CAJ. Krekels EHJ, et al. Among authors: van der graaf ph. CPT Pharmacometrics Syst Pharmacol. 2019 Jan;8(1):34-38. doi: 10.1002/psp4.12366. Epub 2019 Jan 28. CPT Pharmacometrics Syst Pharmacol. 2019. PMID: 30689298 Free PMC article.
230 results