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GPCR Dynamics: Structures in Motion.
Latorraca NR, Venkatakrishnan AJ, Dror RO. Latorraca NR, et al. Among authors: venkatakrishnan aj. Chem Rev. 2017 Jan 11;117(1):139-155. doi: 10.1021/acs.chemrev.6b00177. Epub 2016 Sep 13. Chem Rev. 2017. PMID: 27622975 Free article. Review.
Diverse GPCRs exhibit conserved water networks for stabilization and activation.
Venkatakrishnan AJ, Ma AK, Fonseca R, Latorraca NR, Kelly B, Betz RM, Asawa C, Kobilka BK, Dror RO. Venkatakrishnan AJ, et al. Proc Natl Acad Sci U S A. 2019 Feb 19;116(8):3288-3293. doi: 10.1073/pnas.1809251116. Epub 2019 Feb 6. Proc Natl Acad Sci U S A. 2019. PMID: 30728297 Free PMC article.
Cryptic pocket formation underlies allosteric modulator selectivity at muscarinic GPCRs.
Hollingsworth SA, Kelly B, Valant C, Michaelis JA, Mastromihalis O, Thompson G, Venkatakrishnan AJ, Hertig S, Scammells PJ, Sexton PM, Felder CC, Christopoulos A, Dror RO. Hollingsworth SA, et al. Among authors: venkatakrishnan aj. Nat Commun. 2019 Jul 23;10(1):3289. doi: 10.1038/s41467-019-11062-7. Nat Commun. 2019. PMID: 31337749 Free PMC article.
Structural insights into µ-opioid receptor activation.
Huang W, Manglik A, Venkatakrishnan AJ, Laeremans T, Feinberg EN, Sanborn AL, Kato HE, Livingston KE, Thorsen TS, Kling RC, Granier S, Gmeiner P, Husbands SM, Traynor JR, Weis WI, Steyaert J, Dror RO, Kobilka BK. Huang W, et al. Among authors: venkatakrishnan aj. Nature. 2015 Aug 20;524(7565):315-21. doi: 10.1038/nature14886. Epub 2015 Aug 5. Nature. 2015. PMID: 26245379 Free PMC article.
Crystal Structure of an LSD-Bound Human Serotonin Receptor.
Wacker D, Wang S, McCorvy JD, Betz RM, Venkatakrishnan AJ, Levit A, Lansu K, Schools ZL, Che T, Nichols DE, Shoichet BK, Dror RO, Roth BL. Wacker D, et al. Among authors: venkatakrishnan aj. Cell. 2017 Jan 26;168(3):377-389.e12. doi: 10.1016/j.cell.2016.12.033. Cell. 2017. PMID: 28129538 Free PMC article.
60 results