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Small-molecule WNK inhibition regulates cardiovascular and renal function.
Yamada K, Park HM, Rigel DF, DiPetrillo K, Whalen EJ, Anisowicz A, Beil M, Berstler J, Brocklehurst CE, Burdick DA, Caplan SL, Capparelli MP, Chen G, Chen W, Dale B, Deng L, Fu F, Hamamatsu N, Harasaki K, Herr T, Hoffmann P, Hu QY, Huang WJ, Idamakanti N, Imase H, Iwaki Y, Jain M, Jeyaseelan J, Kato M, Kaushik VK, Kohls D, Kunjathoor V, LaSala D, Lee J, Liu J, Luo Y, Ma F, Mo R, Mowbray S, Mogi M, Ossola F, Pandey P, Patel SJ, Raghavan S, Salem B, Shanado YH, Trakshel GM, Turner G, Wakai H, Wang C, Weldon S, Wielicki JB, Xie X, Xu L, Yagi YI, Yasoshima K, Yin J, Yowe D, Zhang JH, Zheng G, Monovich L. Yamada K, et al. Nat Chem Biol. 2016 Nov;12(11):896-898. doi: 10.1038/nchembio.2168. Epub 2016 Sep 5. Nat Chem Biol. 2016. PMID: 27595330
Discovery and Characterization of Allosteric WNK Kinase Inhibitors.
Yamada K, Zhang JH, Xie X, Reinhardt J, Xie AQ, LaSala D, Kohls D, Yowe D, Burdick D, Yoshisue H, Wakai H, Schmidt I, Gunawan J, Yasoshima K, Yue QK, Kato M, Mogi M, Idamakanti N, Kreder N, Drueckes P, Pandey P, Kawanami T, Huang W, Yagi YI, Deng Z, Park HM. Yamada K, et al. ACS Chem Biol. 2016 Dec 16;11(12):3338-3346. doi: 10.1021/acschembio.6b00511. Epub 2016 Oct 19. ACS Chem Biol. 2016. PMID: 27712055
Optimization of Allosteric With-No-Lysine (WNK) Kinase Inhibitors and Efficacy in Rodent Hypertension Models.
Yamada K, Levell J, Yoon T, Kohls D, Yowe D, Rigel DF, Imase H, Yuan J, Yasoshima K, DiPetrillo K, Monovich L, Xu L, Zhu M, Kato M, Jain M, Idamakanti N, Taslimi P, Kawanami T, Argikar UA, Kunjathoor V, Xie X, Yagi YI, Iwaki Y, Robinson Z, Park HM. Yamada K, et al. J Med Chem. 2017 Aug 24;60(16):7099-7107. doi: 10.1021/acs.jmedchem.7b00708. Epub 2017 Aug 3. J Med Chem. 2017. PMID: 28771350
Discovery of a Novel Piperidine-Based Inhibitor of Cholesteryl Ester Transfer Protein (CETP) That Retains Activity in Hypertriglyceridemic Plasma.
Yamada K, Brousseau M, Honma W, Iimura A, Imase H, Iwaki Y, Kawanami T, LaSala D, Liang G, Mitani H, Nonomura K, Ohmori O, Pan M, Rigel DF, Umemura I, Yasoshima K, Zhu G, Mogi M. Yamada K, et al. J Med Chem. 2017 Oct 26;60(20):8466-8481. doi: 10.1021/acs.jmedchem.7b00900. Epub 2017 Oct 16. J Med Chem. 2017. PMID: 29035537
Correlation Between Nasal Epithelial Injury and In Vitro Cytotoxicity Using a Series of Small Molecule Protein Tyrosine Phosphatase 1B Inhibitors Investigated for Reversal of Leptin Resistance in Obesity.
Brown AP, Saravanan C, Devine P, Magnifico M, Gao J, Beaulieu V, Ma F, Yasoshima K, Barnes-Seeman D, Yamada K. Brown AP, et al. Among authors: yamada k. Int J Toxicol. 2017 Jul/Aug;36(4):303-313. doi: 10.1177/1091581817711877. Epub 2017 Jun 8. Int J Toxicol. 2017. PMID: 28592157
Transient cerebral vasospasm and global amnesia following post-CT contrast.
Kiyoshige N, Watanabe K, Nishimura T, Ito T, Ishihara K, Yamada K. Kiyoshige N, et al. Among authors: yamada k. Radiol Case Rep. 2024 May 17;19(8):3250-3253. doi: 10.1016/j.radcr.2024.04.079. eCollection 2024 Aug. Radiol Case Rep. 2024. PMID: 38800083 Free PMC article.
Contact aspiration for basilar artery occlusion safely reduces the puncture-to-recanalization time.
Hirota S, Fujita K, Ishiwada T, Takahashi S, Hirai S, Sagawa H, Wakabayashi H, Aoyama J, Fujii S, Yamaoka H, Yoshimura M, Shigeta K, Sato Y, Sawada K, Yamada K, Yamamura T, Ishii Y, Obata Y, Hara M, Kawano Y, Yamamoto S, Nemoto S, Sumita K; TMDU-NEST investigators. Hirota S, et al. Among authors: yamada k. Clin Neurol Neurosurg. 2024 May 14;242:108331. doi: 10.1016/j.clineuro.2024.108331. Online ahead of print. Clin Neurol Neurosurg. 2024. PMID: 38795688
Bone-marrow-homing lipid nanoparticles for genome editing in diseased and malignant haematopoietic stem cells.
Lian X, Chatterjee S, Sun Y, Dilliard SA, Moore S, Xiao Y, Bian X, Yamada K, Sung YC, Levine RM, Mayberry K, John S, Liu X, Smith C, Johnson LT, Wang X, Zhang CC, Liu DR, Newby GA, Weiss MJ, Yen JS, Siegwart DJ. Lian X, et al. Among authors: yamada k. Nat Nanotechnol. 2024 May 23. doi: 10.1038/s41565-024-01680-8. Online ahead of print. Nat Nanotechnol. 2024. PMID: 38783058
Associations between dietary diversity and high sensitive C-reactive protein among Japanese workers: findings of a cross-sectional and longitudinal study.
Nakamoto M, Torami K, Bui TT, Tojyo A, Yamada K, Nakamoto A, Hata A, Aki N, Shikama Y, Bando Y, Ichihara T, Minagawa T, Tamura A, Kuwamura Y, Funaki M, Sakai T. Nakamoto M, et al. Among authors: yamada k. Eur J Nutr. 2024 May 23. doi: 10.1007/s00394-024-03389-9. Online ahead of print. Eur J Nutr. 2024. PMID: 38780630
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