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Discovery and evaluation of selective N-type calcium channel blockers: 6-unsubstituted-1,4-dihydropyridine-5-carboxylic acid derivatives.
Yamamoto T, Niwa S, Tokumasu M, Onishi T, Ohno S, Hagihara M, Koganei H, Fujita S, Takeda T, Saitou Y, Iwayama S, Takahara A, Iwata S, Shoji M. Yamamoto T, et al. Among authors: fujita s. Bioorg Med Chem Lett. 2012 Jun 1;22(11):3639-42. doi: 10.1016/j.bmcl.2012.04.051. Epub 2012 Apr 17. Bioorg Med Chem Lett. 2012. PMID: 22560585
Asymmetric synthesis and biological evaluations of (+)- and (-)-6-dimethoxymethyl-1,4-dihydropyridine-3-carboxylic acid derivatives blocking N-type calcium channels.
Yamamoto T, Ohno S, Niwa S, Tokumasu M, Hagihara M, Koganei H, Fujita S, Takeda T, Saitou Y, Iwayama S, Takahara A, Iwata S, Shoji M. Yamamoto T, et al. Among authors: fujita s. Bioorg Med Chem Lett. 2011 Jun 1;21(11):3317-9. doi: 10.1016/j.bmcl.2011.04.007. Epub 2011 Apr 9. Bioorg Med Chem Lett. 2011. PMID: 21514827
Discovery, structure-activity relationship study, and oral analgesic efficacy of cyproheptadine derivatives possessing N-type calcium channel inhibitory activity.
Yamamoto T, Niwa S, Iwayama S, Koganei H, Fujita S, Takeda T, Kito M, Ono Y, Saitou Y, Takahara A, Iwata S, Yamamoto H, Shoji M. Yamamoto T, et al. Among authors: fujita s. Bioorg Med Chem. 2006 Aug 1;14(15):5333-9. doi: 10.1016/j.bmc.2006.03.040. Epub 2006 Apr 17. Bioorg Med Chem. 2006. PMID: 16616501
The structure-activity relationship study on 2-, 5-, and 6-position of the water soluble 1,4-dihydropyridine derivatives blocking N-type calcium channels.
Yamamoto T, Niwa S, Ohno S, Tokumasu M, Masuzawa Y, Nakanishi C, Nakajo A, Onishi T, Koganei H, Fujita S, Takeda T, Kito M, Ono Y, Saitou Y, Takahara A, Iwata S, Shoji M. Yamamoto T, et al. Among authors: fujita s. Bioorg Med Chem Lett. 2008 Sep 1;18(17):4813-6. doi: 10.1016/j.bmcl.2008.07.096. Epub 2008 Jul 27. Bioorg Med Chem Lett. 2008. PMID: 18684623
3,504 results