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Modification of the genetic program of human alveolar macrophages by adenovirus vectors in vitro is feasible but inefficient, limited in part by the low level of expression of the coxsackie/adenovirus receptor.
Kaner RJ, Worgall S, Leopold PL, Stolze E, Milano E, Hidaka C, Ramalingam R, Hackett NR, Singh R, Bergelson J, Finberg R, Falck-Pedersen E, Crystal RG. Kaner RJ, et al. Am J Respir Cell Mol Biol. 1999 Mar;20(3):361-70. doi: 10.1165/ajrcmb.20.3.3398. Am J Respir Cell Mol Biol. 1999. PMID: 10030833
Airway epithelial CFTR mRNA expression in cystic fibrosis patients after repetitive administration of a recombinant adenovirus.
Harvey BG, Leopold PL, Hackett NR, Grasso TM, Williams PM, Tucker AL, Kaner RJ, Ferris B, Gonda I, Sweeney TD, Ramalingam R, Kovesdi I, Shak S, Crystal RG. Harvey BG, et al. Among authors: kaner rj. J Clin Invest. 1999 Nov;104(9):1245-55. doi: 10.1172/JCI7935. J Clin Invest. 1999. PMID: 10545523 Free PMC article. Clinical Trial.
Analysis of risk factors for local delivery of low- and intermediate-dose adenovirus gene transfer vectors to individuals with a spectrum of comorbid conditions.
Crystal RG, Harvey BG, Wisnivesky JP, O'Donoghue KA, Chu KW, Maroni J, Muscat JC, Pippo AL, Wright CE, Kaner RJ, Leopold PL, Kessler PD, Rasmussen HS, Rosengart TK, Hollmann C. Crystal RG, et al. Among authors: kaner rj. Hum Gene Ther. 2002 Jan 1;13(1):65-100. doi: 10.1089/10430340152712647. Hum Gene Ther. 2002. PMID: 11779413 Clinical Trial.
158 results