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Synthesis and biological evaluation of 2-fluoro and 3-trifluoromethyl-phenyl-piperazinylalkyl derivatives of 1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione as potential antidepressant agents.
Zagórska A, Bucki A, Kołaczkowski M, Siwek A, Głuch-Lutwin M, Starowicz G, Kazek G, Partyka A, Wesołowska A, Słoczyńska K, Pękala E, Pawłowski M. Zagórska A, et al. Among authors: kazek g. J Enzyme Inhib Med Chem. 2016;31(sup3):10-24. doi: 10.1080/14756366.2016.1198902. Epub 2016 Jun 29. J Enzyme Inhib Med Chem. 2016. PMID: 27353547
Influence of analgesic active 3-[4-(3-trifluoromethyl-phenyl)-piperazin-1-yl]-dihydrofuran-2-one on the antioxidant status, glucose utilization and lipid accumulation in some in vitro and ex vivo assays.
Sałat K, Głuch-Lutwin M, Nawieśniak B, Gawlik K, Pawlica-Gosiewska D, Witalis J, Kazek G, Filipek B, Librowski T, Więckowski K, Solnica B. Sałat K, et al. Among authors: kazek g. Toxicol Mech Methods. 2014 Mar;24(3):204-11. doi: 10.3109/15376516.2013.879973. Epub 2014 Jan 17. Toxicol Mech Methods. 2014. PMID: 24392931
Novel arylsulfonamide derivatives with 5-HT₆/5-HT₇ receptor antagonism targeting behavioral and psychological symptoms of dementia.
Kołaczkowski M, Marcinkowska M, Bucki A, Pawłowski M, Mitka K, Jaśkowska J, Kowalski P, Kazek G, Siwek A, Wasik A, Wesołowska A, Mierzejewski P, Bienkowski P. Kołaczkowski M, et al. Among authors: kazek g. J Med Chem. 2014 Jun 12;57(11):4543-57. doi: 10.1021/jm401895u. Epub 2014 May 23. J Med Chem. 2014. PMID: 24805037
Novel 5-HT6 receptor antagonists/D2 receptor partial agonists targeting behavioral and psychological symptoms of dementia.
Kołaczkowski M, Marcinkowska M, Bucki A, Śniecikowska J, Pawłowski M, Kazek G, Siwek A, Jastrzębska-Więsek M, Partyka A, Wasik A, Wesołowska A, Mierzejewski P, Bienkowski P. Kołaczkowski M, et al. Among authors: kazek g. Eur J Med Chem. 2015 Mar 6;92:221-35. doi: 10.1016/j.ejmech.2014.12.045. Epub 2014 Dec 24. Eur J Med Chem. 2015. PMID: 25557493
Structure-activity relationships and molecular studies of novel arylpiperazinylalkyl purine-2,4-diones and purine-2,4,8-triones with antidepressant and anxiolytic-like activity.
Zagórska A, Kołaczkowski M, Bucki A, Siwek A, Kazek G, Satała G, Bojarski AJ, Partyka A, Wesołowska A, Pawłowski M. Zagórska A, et al. Among authors: kazek g. Eur J Med Chem. 2015 Jun 5;97:142-54. doi: 10.1016/j.ejmech.2015.04.046. Epub 2015 May 1. Eur J Med Chem. 2015. PMID: 25965777
The antidepressant-like activity of 6-methoxy-2-[4-(2-methoxyphenyl)piperazin-1-yl]-9H-xanthen-9-one involves serotonergic 5-HT(1A) and 5-HT(2A/C) receptors activation.
Pytka K, Walczak M, Kij A, Rapacz A, Siwek A, Kazek G, Olczyk A, Gałuszka A, Waszkielewicz A, Marona H, Sapa J, Filipek B. Pytka K, et al. Among authors: kazek g. Eur J Pharmacol. 2015 Oct 5;764:537-546. doi: 10.1016/j.ejphar.2015.07.041. Epub 2015 Jul 22. Eur J Pharmacol. 2015. PMID: 26210317
37 results