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Proteome analysis of mast cell releasates reveals a role for chymase in the regulation of coagulation factor XIIIA levels via proteolytic degradation.
Shubin NJ, Glukhova VA, Clauson M, Truong P, Abrink M, Pejler G, White NJ, Deutsch GH, Reeves SR, Vaisar T, James RG, Piliponsky AM. Shubin NJ, et al. Among authors: pejler g. J Allergy Clin Immunol. 2017 Jan;139(1):323-334. doi: 10.1016/j.jaci.2016.03.051. Epub 2016 May 13. J Allergy Clin Immunol. 2017. PMID: 27302551 Free PMC article.
Thrombin is inactivated by mast cell secretory granule chymase.
Pejler G, Karlström A. Pejler G, et al. J Biol Chem. 1993 Jun 5;268(16):11817-22. J Biol Chem. 1993. PMID: 8505310 Free article.
In a recent paper we demonstrated that cultures of murine adherent peritoneal cells expressed cell surface-associated serine protease activity that specifically inactivated thrombin by cleaving the enzyme into defined proteolytic fragments (Pejler, G., and Seljelid, …
In a recent paper we demonstrated that cultures of murine adherent peritoneal cells expressed cell surface-associated serine protease activi …
Human mast cell beta-tryptase is a gelatinase.
Fajardo I, Pejler G. Fajardo I, et al. Among authors: pejler g. J Immunol. 2003 Aug 1;171(3):1493-9. doi: 10.4049/jimmunol.171.3.1493. J Immunol. 2003. PMID: 12874242
227 results