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A road map for prioritizing warheads for cysteine targeting covalent inhibitors.
Ábrányi-Balogh P, Petri L, Imre T, Szijj P, Scarpino A, Hrast M, Mitrović A, Fonovič UP, Németh K, Barreteau H, Roper DI, Horváti K, Ferenczy GG, Kos J, Ilaš J, Gobec S, Keserű GM. Ábrányi-Balogh P, et al. Among authors: imre t. Eur J Med Chem. 2018 Dec 5;160:94-107. doi: 10.1016/j.ejmech.2018.10.010. Epub 2018 Oct 6. Eur J Med Chem. 2018. PMID: 30321804
Electrophilic MiniFrags Revealed Unprecedented Binding Sites for Covalent HDAC8 Inhibitors.
Keeley AB, Kopranovic A, Di Lorenzo V, Ábrányi-Balogh P, Jänsch N, Lai LN, Petri L, Orgován Z, Pölöske D, Orlova A, Németh AG, Desczyk C, Imre T, Bajusz D, Moriggl R, Meyer-Almes FJ, Keserü GM. Keeley AB, et al. Among authors: imre t. J Med Chem. 2024 Jan 11;67(1):572-585. doi: 10.1021/acs.jmedchem.3c01779. Epub 2023 Dec 19. J Med Chem. 2024. PMID: 38113354 Free PMC article.
Cysteine specific bioconjugation with benzyl isothiocyanates.
Petri L, Szijj PA, Kelemen Á, Imre T, Gömöry Á, Lee MTW, Hegedűs K, Ábrányi-Balogh P, Chudasama V, Keserű GM. Petri L, et al. Among authors: imre t. RSC Adv. 2020 Apr 16;10(25):14928-14936. doi: 10.1039/d0ra02934c. eCollection 2020 Apr 8. RSC Adv. 2020. PMID: 35497170 Free PMC article.
43 results