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Phosphoinositide 3-kinase inhibitors induce DNA damage through nucleoside depletion.
Juvekar A, Hu H, Yadegarynia S, Lyssiotis CA, Ullas S, Lien EC, Bellinger G, Son J, Hok RC, Seth P, Daly MB, Kim B, Scully R, Asara JM, Cantley LC, Wulf GM. Juvekar A, et al. Among authors: bellinger g. Proc Natl Acad Sci U S A. 2016 Jul 26;113(30):E4338-47. doi: 10.1073/pnas.1522223113. Epub 2016 Jul 8. Proc Natl Acad Sci U S A. 2016. PMID: 27402769 Free PMC article.
ErbB2 is required for ductal morphogenesis of the mammary gland.
Jackson-Fisher AJ, Bellinger G, Ramabhadran R, Morris JK, Lee KF, Stern DF. Jackson-Fisher AJ, et al. Among authors: bellinger g. Proc Natl Acad Sci U S A. 2004 Dec 7;101(49):17138-43. doi: 10.1073/pnas.0407057101. Epub 2004 Nov 29. Proc Natl Acad Sci U S A. 2004. PMID: 15569931 Free PMC article.
Formation of Neu/ErbB2-induced mammary tumors is unaffected by loss of ErbB4.
Jackson-Fisher AJ, Bellinger G, Shum E, Duong JK, Perkins AS, Gassmann M, Muller W, Kent Lloyd KC, Stern DF. Jackson-Fisher AJ, et al. Among authors: bellinger g. Oncogene. 2006 Sep 14;25(41):5664-72. doi: 10.1038/sj.onc.1209574. Epub 2006 May 1. Oncogene. 2006. PMID: 16652155
Metformin decreases glucose oxidation and increases the dependency of prostate cancer cells on reductive glutamine metabolism.
Fendt SM, Bell EL, Keibler MA, Davidson SM, Wirth GJ, Fiske B, Mayers JR, Schwab M, Bellinger G, Csibi A, Patnaik A, Blouin MJ, Cantley LC, Guarente L, Blenis J, Pollak MN, Olumi AF, Vander Heiden MG, Stephanopoulos G. Fendt SM, et al. Among authors: bellinger g. Cancer Res. 2013 Jul 15;73(14):4429-38. doi: 10.1158/0008-5472.CAN-13-0080. Epub 2013 May 17. Cancer Res. 2013. PMID: 23687346 Free PMC article.
ErbB3 is required for ductal morphogenesis in the mouse mammary gland.
Jackson-Fisher AJ, Bellinger G, Breindel JL, Tavassoli FA, Booth CJ, Duong JK, Stern DF. Jackson-Fisher AJ, et al. Among authors: bellinger g. Breast Cancer Res. 2008;10(6):R96. doi: 10.1186/bcr2198. Epub 2008 Nov 18. Breast Cancer Res. 2008. PMID: 19019207 Free PMC article.
Depletion of a putatively druggable class of phosphatidylinositol kinases inhibits growth of p53-null tumors.
Emerling BM, Hurov JB, Poulogiannis G, Tsukazawa KS, Choo-Wing R, Wulf GM, Bell EL, Shim HS, Lamia KA, Rameh LE, Bellinger G, Sasaki AT, Asara JM, Yuan X, Bullock A, Denicola GM, Song J, Brown V, Signoretti S, Cantley LC. Emerling BM, et al. Among authors: bellinger g. Cell. 2013 Nov 7;155(4):844-57. doi: 10.1016/j.cell.2013.09.057. Cell. 2013. PMID: 24209622 Free PMC article.
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