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Synthesis and biological evaluation of 2-fluoro and 3-trifluoromethyl-phenyl-piperazinylalkyl derivatives of 1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione as potential antidepressant agents.
Zagórska A, Bucki A, Kołaczkowski M, Siwek A, Głuch-Lutwin M, Starowicz G, Kazek G, Partyka A, Wesołowska A, Słoczyńska K, Pękala E, Pawłowski M. Zagórska A, et al. Among authors: kazek g. J Enzyme Inhib Med Chem. 2016;31(sup3):10-24. doi: 10.1080/14756366.2016.1198902. Epub 2016 Jun 29. J Enzyme Inhib Med Chem. 2016. PMID: 27353547
Structure-5-HT/D2 Receptor Affinity Relationship in a New Group of 1-Arylpiperazynylalkyl Derivatives of 8-Dialkylamino-3,7-dimethyl-1H-purine-2,6(3H,7H)-dione.
Żmudzki P, Satała G, Chłoń-Rzepa G, Bojarski AJ, Kazek G, Siwek A, Gryboś A, Głuch-Lutwin M, Wesołowska A, Pawłowski M. Żmudzki P, et al. Among authors: kazek g. Arch Pharm (Weinheim). 2016 Oct;349(10):774-784. doi: 10.1002/ardp.201600162. Epub 2016 Aug 11. Arch Pharm (Weinheim). 2016. PMID: 27510801
Structure-activity relationships and molecular studies of novel arylpiperazinylalkyl purine-2,4-diones and purine-2,4,8-triones with antidepressant and anxiolytic-like activity.
Zagórska A, Kołaczkowski M, Bucki A, Siwek A, Kazek G, Satała G, Bojarski AJ, Partyka A, Wesołowska A, Pawłowski M. Zagórska A, et al. Among authors: kazek g. Eur J Med Chem. 2015 Jun 5;97:142-54. doi: 10.1016/j.ejmech.2015.04.046. Epub 2015 May 1. Eur J Med Chem. 2015. PMID: 25965777
Aminoalkyl Derivatives of 8-Alkoxypurine-2,6-diones: Multifunctional 5-HT1A /5-HT7 Receptor Ligands and PDE Inhibitors with Antidepressant Activity.
Chłoń-Rzepa G, Zagórska A, Żmudzki P, Bucki A, Kołaczkowski M, Partyka A, Wesołowska A, Kazek G, Głuch-Lutwin M, Siwek A, Starowicz G, Pawłowski M. Chłoń-Rzepa G, et al. Among authors: kazek g. Arch Pharm (Weinheim). 2016 Dec;349(12):889-903. doi: 10.1002/ardp.201600260. Epub 2016 Nov 21. Arch Pharm (Weinheim). 2016. PMID: 27869315
Arylpiperazinylalkyl derivatives of 8-amino-1,3-dimethylpurine-2,6-dione as novel multitarget 5-HT/D receptor agents with potential antipsychotic activity.
Chłoń-Rzepa G, Bucki A, Kołaczkowski M, Partyka A, Jastrzębska-Więsek M, Satała G, Bojarski AJ, Kalinowska-Tłuścik J, Kazek G, Mordyl B, Głuch-Lutwin M, Wesołowska A. Chłoń-Rzepa G, et al. Among authors: kazek g. J Enzyme Inhib Med Chem. 2016 Dec;31(6):1048-62. doi: 10.3109/14756366.2015.1088844. Epub 2015 Sep 25. J Enzyme Inhib Med Chem. 2016. PMID: 26406608
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