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Conversion of Synthetic Aβ to In Vivo Active Seeds and Amyloid Plaque Formation in a Hippocampal Slice Culture Model.
Novotny R, Langer F, Mahler J, Skodras A, Vlachos A, Wegenast-Braun BM, Kaeser SA, Neher JJ, Eisele YS, Pietrowski MJ, Nilsson KP, Deller T, Staufenbiel M, Heimrich B, Jucker M. Novotny R, et al. Among authors: nilsson kp. J Neurosci. 2016 May 4;36(18):5084-93. doi: 10.1523/JNEUROSCI.0258-16.2016. J Neurosci. 2016. PMID: 27147660 Free PMC article.
Novel pentameric thiophene derivatives for in vitro and in vivo optical imaging of a plethora of protein aggregates in cerebral amyloidoses.
Aslund A, Sigurdson CJ, Klingstedt T, Grathwohl S, Bolmont T, Dickstein DL, Glimsdal E, Prokop S, Lindgren M, Konradsson P, Holtzman DM, Hof PR, Heppner FL, Gandy S, Jucker M, Aguzzi A, Hammarström P, Nilsson KP. Aslund A, et al. Among authors: nilsson kp. ACS Chem Biol. 2009 Aug 21;4(8):673-84. doi: 10.1021/cb900112v. ACS Chem Biol. 2009. PMID: 19624097 Free PMC article.
Prion strain interactions are highly selective.
Nilsson KP, Joshi-Barr S, Winson O, Sigurdson CJ. Nilsson KP, et al. J Neurosci. 2010 Sep 8;30(36):12094-102. doi: 10.1523/JNEUROSCI.2417-10.2010. J Neurosci. 2010. PMID: 20826672 Free PMC article.
Evidence for age-dependent in vivo conformational rearrangement within Aβ amyloid deposits.
Nyström S, Psonka-Antonczyk KM, Ellingsen PG, Johansson LB, Reitan N, Handrick S, Prokop S, Heppner FL, Wegenast-Braun BM, Jucker M, Lindgren M, Stokke BT, Hammarström P, Nilsson KP. Nyström S, et al. Among authors: nilsson kp. ACS Chem Biol. 2013;8(6):1128-33. doi: 10.1021/cb4000376. Epub 2013 Mar 29. ACS Chem Biol. 2013. PMID: 23521783
Seeded strain-like transmission of β-amyloid morphotypes in APP transgenic mice.
Heilbronner G, Eisele YS, Langer F, Kaeser SA, Novotny R, Nagarathinam A, Aslund A, Hammarström P, Nilsson KP, Jucker M. Heilbronner G, et al. Among authors: nilsson kp. EMBO Rep. 2013 Nov;14(11):1017-22. doi: 10.1038/embor.2013.137. Epub 2013 Sep 3. EMBO Rep. 2013. PMID: 23999102 Free PMC article.
Aβ seeds resist inactivation by formaldehyde.
Fritschi SK, Cintron A, Ye L, Mahler J, Bühler A, Baumann F, Neumann M, Nilsson KP, Hammarström P, Walker LC, Jucker M. Fritschi SK, et al. Among authors: nilsson kp. Acta Neuropathol. 2014 Oct;128(4):477-84. doi: 10.1007/s00401-014-1339-2. Epub 2014 Sep 6. Acta Neuropathol. 2014. PMID: 25193240 Free PMC article.
Endogenous murine Aβ increases amyloid deposition in APP23 but not in APPPS1 transgenic mice.
Mahler J, Morales-Corraliza J, Stolz J, Skodras A, Radde R, Duma CC, Eisele YS, Mazzella MJ, Wong H, Klunk WE, Nilsson KPR, Staufenbiel M, Mathews PM, Jucker M, Wegenast-Braun BM. Mahler J, et al. Neurobiol Aging. 2015 Jul;36(7):2241-2247. doi: 10.1016/j.neurobiolaging.2015.03.011. Epub 2015 Mar 25. Neurobiol Aging. 2015. PMID: 25911278 Free PMC article.
154 results