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The antidepressant-like activity of 6-methoxy-2-[4-(2-methoxyphenyl)piperazin-1-yl]-9H-xanthen-9-one involves serotonergic 5-HT(1A) and 5-HT(2A/C) receptors activation.
Pytka K, Walczak M, Kij A, Rapacz A, Siwek A, Kazek G, Olczyk A, Gałuszka A, Waszkielewicz A, Marona H, Sapa J, Filipek B. Pytka K, et al. Among authors: olczyk a. Eur J Pharmacol. 2015 Oct 5;764:537-546. doi: 10.1016/j.ejphar.2015.07.041. Epub 2015 Jul 22. Eur J Pharmacol. 2015. PMID: 26210317
Antidepressant- and Anxiolytic-Like Effects of New Dual 5-HT₁A and 5-HT₇ Antagonists in Animal Models.
Pytka K, Partyka A, Jastrzębska-Więsek M, Siwek A, Głuch-Lutwin M, Mordyl B, Kazek G, Rapacz A, Olczyk A, Gałuszka A, Błachuta M, Waszkielewicz A, Marona H, Sapa J, Filipek B, Wesołowska A. Pytka K, et al. Among authors: olczyk a. PLoS One. 2015 Nov 10;10(11):e0142499. doi: 10.1371/journal.pone.0142499. eCollection 2015. PLoS One. 2015. PMID: 26554929 Free PMC article.
Chemically Homogenous Compounds with Antagonistic Properties at All α1-Adrenoceptor Subtypes but not β1-Adrenoceptor Attenuate Adrenaline-Induced Arrhythmia in Rats.
Pytka K, Lustyk K, Żmudzka E, Kotańska M, Siwek A, Zygmunt M, Dziedziczak A, Śniecikowska J, Olczyk A, Gałuszka A, Śmieja J, Waszkielewicz AM, Marona H, Filipek B, Sapa J, Mogilski S. Pytka K, et al. Among authors: olczyk a. Front Pharmacol. 2016 Aug 3;7:229. doi: 10.3389/fphar.2016.00229. eCollection 2016. Front Pharmacol. 2016. PMID: 27536240 Free PMC article.
HBK-17, a 5-HT1A Receptor Ligand With Anxiolytic-Like Activity, Preferentially Activates ß-Arrestin Signaling.
Pytka K, Głuch-Lutwin M, Żmudzka E, Sałaciak K, Siwek A, Niemczyk K, Walczak M, Smolik M, Olczyk A, Gałuszka A, Śmieja J, Filipek B, Sapa J, Kołaczkowski M, Pańczyk K, Waszkielewicz A, Marona H. Pytka K, et al. Among authors: olczyk a. Front Pharmacol. 2018 Oct 16;9:1146. doi: 10.3389/fphar.2018.01146. eCollection 2018. Front Pharmacol. 2018. PMID: 30410441 Free PMC article.
15 results