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Amine-free melanin-concentrating hormone receptor 1 antagonists: Novel non-basic 1-(2H-indazole-5-yl)pyridin-2(1H)-one derivatives and mitigation of mutagenicity in Ames test.
Igawa H, Takahashi M, Ikoma M, Kaku H, Kakegawa K, Kina A, Aida J, Okuda S, Kawata Y, Noguchi T, Hotta N, Yamamoto S, Nakayama M, Nagisa Y, Kasai S, Maekawa T. Igawa H, et al. Among authors: hotta n. Bioorg Med Chem. 2016 Jun 1;24(11):2504-2518. doi: 10.1016/j.bmc.2016.04.013. Epub 2016 Apr 7. Bioorg Med Chem. 2016. PMID: 27117261
A novel and selective melanin-concentrating hormone receptor 1 antagonist ameliorates obesity and hepatic steatosis in diet-induced obese rodent models.
Kawata Y, Okuda S, Hotta N, Igawa H, Takahashi M, Ikoma M, Kasai S, Ando A, Satomi Y, Nishida M, Nakayama M, Yamamoto S, Nagisa Y, Takekawa S. Kawata Y, et al. Among authors: hotta n. Eur J Pharmacol. 2017 Feb 5;796:45-53. doi: 10.1016/j.ejphar.2016.12.018. Epub 2016 Dec 13. Eur J Pharmacol. 2017. PMID: 27986627
Bombesin receptor subtype-3-expressing neurons regulate energy homeostasis through a novel neuronal pathway in the hypothalamus.
Maruyama M, Hotta N, Nio Y, Hamagami K, Nagi T, Funata M, Sakamoto J, Nakakariya M, Amano N, Nishida M, Okawa T, Arikawa Y, Sasaki S, Kasai S, Nagisa Y, Habata Y, Mori M. Maruyama M, et al. Among authors: hotta n. Brain Behav. 2017 Dec 15;8(1):e00881. doi: 10.1002/brb3.881. eCollection 2018 Jan. Brain Behav. 2017. PMID: 29568682 Free PMC article.
362 results