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Identification of a 1,2,4,5-tetraoxane antimalarial drug-development candidate (RKA 182) with superior properties to the semisynthetic artemisinins.
O'Neill PM, Amewu RK, Nixon GL, Bousejra ElGarah F, Mungthin M, Chadwick J, Shone AE, Vivas L, Lander H, Barton V, Muangnoicharoen S, Bray PG, Davies J, Park BK, Wittlin S, Brun R, Preschel M, Zhang K, Ward SA. O'Neill PM, et al. Angew Chem Int Ed Engl. 2010 Aug 2;49(33):5693-7. doi: 10.1002/anie.201001026. Angew Chem Int Ed Engl. 2010. PMID: 20629058 No abstract available.
Evidence for a common non-heme chelatable-iron-dependent activation mechanism for semisynthetic and synthetic endoperoxide antimalarial drugs.
Stocks PA, Bray PG, Barton VE, Al-Helal M, Jones M, Araujo NC, Gibbons P, Ward SA, Hughes RH, Biagini GA, Davies J, Amewu R, Mercer AE, Ellis G, O'Neill PM. Stocks PA, et al. Among authors: barton ve. Angew Chem Int Ed Engl. 2007;46(33):6278-83. doi: 10.1002/anie.200604697. Angew Chem Int Ed Engl. 2007. PMID: 17640025 No abstract available.
A Click Chemistry-Based Proteomic Approach Reveals that 1,2,4-Trioxolane and Artemisinin Antimalarials Share a Common Protein Alkylation Profile.
Ismail HM, Barton VE, Panchana M, Charoensutthivarakul S, Biagini GA, Ward SA, O'Neill PM. Ismail HM, et al. Among authors: barton ve. Angew Chem Weinheim Bergstr Ger. 2016 May 23;128(22):6511-6515. doi: 10.1002/ange.201512062. Epub 2016 Apr 18. Angew Chem Weinheim Bergstr Ger. 2016. PMID: 27397940 Free PMC article.
Corrigendum: A Click Chemistry-Based Proteomic Approach Reveals that 1,2,4-Trioxolane and Artemisinin Antimalarials Share a Common Protein Alkylation Profile.
Ismail HM, Barton VE, Panchana M, Charoensutthivarakul S, Biagini GA, Ward SA, O'Neill PM. Ismail HM, et al. Among authors: barton ve. Angew Chem Int Ed Engl. 2016 Aug 26;55(36):10548. doi: 10.1002/anie.201607032. Angew Chem Int Ed Engl. 2016. PMID: 27552550 Free PMC article. No abstract available.
Inhibiting Plasmodium cytochrome bc1: a complex issue.
Barton V, Fisher N, Biagini GA, Ward SA, O'Neill PM. Barton V, et al. Curr Opin Chem Biol. 2010 Aug;14(4):440-6. doi: 10.1016/j.cbpa.2010.05.005. Curr Opin Chem Biol. 2010. PMID: 20570550 Review.
13 results