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A gain-of-function variant in DIAPH1 causes dominant macrothrombocytopenia and hearing loss.
Stritt S, Nurden P, Turro E, Greene D, Jansen SB, Westbury SK, Petersen R, Astle WJ, Marlin S, Bariana TK, Kostadima M, Lentaigne C, Maiwald S, Papadia S, Kelly AM, Stephens JC, Penkett CJ, Ashford S, Tuna S, Austin S, Bakchoul T, Collins P, Favier R, Lambert MP, Mathias M, Millar CM, Mapeta R, Perry DJ, Schulman S, Simeoni I, Thys C; BRIDGE-BPD Consortium; Gomez K, Erber WN, Stirrups K, Rendon A, Bradley JR, van Geet C, Raymond FL, Laffan MA, Nurden AT, Nieswandt B, Richardson S, Freson K, Ouwehand WH, Mumford AD. Stritt S, et al. Blood. 2016 Jun 9;127(23):2903-14. doi: 10.1182/blood-2015-10-675629. Epub 2016 Feb 24. Blood. 2016. PMID: 26912466 Free article.
Megakaryocyte-specific Profilin1-deficiency alters microtubule stability and causes a Wiskott-Aldrich syndrome-like platelet defect.
Bender M, Stritt S, Nurden P, van Eeuwijk JM, Zieger B, Kentouche K, Schulze H, Morbach H, Stegner D, Heinze KG, Dütting S, Gupta S, Witke W, Falet H, Fischer A, Hartwig JH, Nieswandt B. Bender M, et al. Among authors: stritt s. Nat Commun. 2014 Sep 4;5:4746. doi: 10.1038/ncomms5746. Nat Commun. 2014. PMID: 25187265 Free article.
In vitro platelets in sight.
Stritt S, Nieswandt B. Stritt S, et al. Blood. 2014 Sep 18;124(12):1849-50. doi: 10.1182/blood-2014-08-592493. Blood. 2014. PMID: 25606626 Free article. No abstract available.
Megakaryocyte rupture for acute platelet needs.
Nieswandt B, Stritt S. Nieswandt B, et al. Among authors: stritt s. J Cell Biol. 2015 May 11;209(3):327-8. doi: 10.1083/jcb.201504026. J Cell Biol. 2015. PMID: 25963815 Free PMC article. Review.
Defects in TRPM7 channel function deregulate thrombopoiesis through altered cellular Mg(2+) homeostasis and cytoskeletal architecture.
Stritt S, Nurden P, Favier R, Favier M, Ferioli S, Gotru SK, van Eeuwijk JM, Schulze H, Nurden AT, Lambert MP, Turro E, Burger-Stritt S, Matsushita M, Mittermeier L, Ballerini P, Zierler S, Laffan MA, Chubanov V, Gudermann T, Nieswandt B, Braun A. Stritt S, et al. Nat Commun. 2016 Mar 29;7:11097. doi: 10.1038/ncomms11097. Nat Commun. 2016. PMID: 27020697 Free PMC article.
A Cdc42/RhoA regulatory circuit downstream of glycoprotein Ib guides transendothelial platelet biogenesis.
Dütting S, Gaits-Iacovoni F, Stegner D, Popp M, Antkowiak A, van Eeuwijk JMM, Nurden P, Stritt S, Heib T, Aurbach K, Angay O, Cherpokova D, Heinz N, Baig AA, Gorelashvili MG, Gerner F, Heinze KG, Ware J, Krohne G, Ruggeri ZM, Nurden AT, Schulze H, Modlich U, Pleines I, Brakebusch C, Nieswandt B. Dütting S, et al. Among authors: stritt s. Nat Commun. 2017 Jun 15;8:15838. doi: 10.1038/ncomms15838. Nat Commun. 2017. PMID: 28643773 Free PMC article.
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