Bretz AC - Search Results

1

ΔNp63 activates the Fanconi anemia DNA repair pathway and limits the efficacy of cisplatin treatment in squamous cell carcinoma.

Bretz AC, Gittler MP, Charles JP, Gremke N, Eckhardt I, Mernberger M, Mandic R, Thomale J, Nist A, Wanzel M, Stiewe T. Bretz AC, et al. Nucleic Acids Res. 2016 Apr 20;44(7):3204-18. doi: 10.1093/nar/gkw036. Epub 2016 Jan 26. Nucleic Acids Res. 2016. PMID: 26819410 Free PMC article.

2

CRISPR-Cas9-based target validation for p53-reactivating model compounds.

Wanzel M, Vischedyk JB, Gittler MP, Gremke N, Seiz JR, Hefter M, Noack M, Savai R, Mernberger M, Charles JP, Schneikert J, Bretz AC, Nist A, Stiewe T. Wanzel M, et al. Among authors: bretz ac. Nat Chem Biol. 2016 Jan;12(1):22-8. doi: 10.1038/nchembio.1965. Epub 2015 Nov 23. Nat Chem Biol. 2016. PMID: 26595461 Free PMC article.

3

DNA binding cooperativity of p53 modulates the decision between cell-cycle arrest and apoptosis.

Schlereth K, Beinoraviciute-Kellner R, Zeitlinger MK, Bretz AC, Sauer M, Charles JP, Vogiatzi F, Leich E, Samans B, Eilers M, Kisker C, Rosenwald A, Stiewe T. Schlereth K, et al. Among authors: bretz ac. Mol Cell. 2010 May 14;38(3):356-68. doi: 10.1016/j.molcel.2010.02.037. Mol Cell. 2010. PMID: 20471942 Free article.

4

Life or death: p53-induced apoptosis requires DNA binding cooperativity.

Schlereth K, Charles JP, Bretz AC, Stiewe T. Schlereth K, et al. Among authors: bretz ac. Cell Cycle. 2010 Oct 15;9(20):4068-76. doi: 10.4161/cc.9.20.13595. Epub 2010 Oct 11. Cell Cycle. 2010. PMID: 20948308 Free PMC article.

5

A cisplatin-resistant head and neck cancer cell line with cytoplasmic p53(mut) exhibits ATP-binding cassette transporter upregulation and high glutathione levels.

Tonigold M, Rossmann A, Meinold M, Bette M, Märken M, Henkenius K, Bretz AC, Giel G, Cai C, Rodepeter FR, Beneš V, Grénman R, Carey TE, Lage H, Stiewe T, Neubauer A, Werner JA, Brendel C, Mandic R. Tonigold M, et al. Among authors: bretz ac. J Cancer Res Clin Oncol. 2014 Oct;140(10):1689-704. doi: 10.1007/s00432-014-1727-y. Epub 2014 Jun 10. J Cancer Res Clin Oncol. 2014. PMID: 24913304

6

C-terminal diversity within the p53 family accounts for differences in DNA binding and transcriptional activity.

Sauer M, Bretz AC, Beinoraviciute-Kellner R, Beitzinger M, Burek C, Rosenwald A, Harms GS, Stiewe T. Sauer M, et al. Among authors: bretz ac. Nucleic Acids Res. 2008 Apr;36(6):1900-12. doi: 10.1093/nar/gkn044. Epub 2008 Feb 11. Nucleic Acids Res. 2008. PMID: 18267967 Free PMC article.

7

Targeting p73 in cancer.

Maas AM, Bretz AC, Mack E, Stiewe T. Maas AM, et al. Among authors: bretz ac. Cancer Lett. 2013 May 28;332(2):229-36. doi: 10.1016/j.canlet.2011.07.030. Epub 2011 Aug 22. Cancer Lett. 2013. PMID: 21903324 Review.

8

p73 poses a barrier to malignant transformation by limiting anchorage-independent growth.

Beitzinger M, Hofmann L, Oswald C, Beinoraviciute-Kellner R, Sauer M, Griesmann H, Bretz AC, Burek C, Rosenwald A, Stiewe T. Beitzinger M, et al. Among authors: bretz ac. EMBO J. 2008 Mar 5;27(5):792-803. doi: 10.1038/emboj.2008.13. Epub 2008 Jan 31. EMBO J. 2008. PMID: 18239687 Free PMC article.

9

The Nuclear Proteins TP73 and CUL4A Confer Resistance to Cytarabine by Induction of Translesion DNA Synthesis via Mono-ubiquitination of PCNA.

Rehberger M, Schäfer JA, Krampitz AM, Bretz AC, Jost L, Haferlach T, Stiewe T, Neubauer A. Rehberger M, et al. Among authors: bretz ac. Hemasphere. 2022 Apr 26;6(5):e0708. doi: 10.1097/HS9.0000000000000708. eCollection 2022 May. Hemasphere. 2022. PMID: 35519003 Free PMC article.

10

The HDAC Inhibitor Domatinostat Promotes Cell-Cycle Arrest, Induces Apoptosis, and Increases Immunogenicity of Merkel Cell Carcinoma Cells.

Song L, Bretz AC, Gravemeyer J, Spassova I, Muminova S, Gambichler T, Sriram A, Ferrone S, Becker JC. Song L, et al. Among authors: bretz ac. J Invest Dermatol. 2021 Apr;141(4):903-912.e4. doi: 10.1016/j.jid.2020.08.023. Epub 2020 Sep 28. J Invest Dermatol. 2021. PMID: 33002502 Free PMC article.

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