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Synthesis and Characterization of Fatty Acid Conjugates of Niacin and Salicylic Acid.
Vu CB, Bemis JE, Benson E, Bista P, Carney D, Fahrner R, Lee D, Liu F, Lonkar P, Milne JC, Nichols AJ, Picarella D, Shoelson A, Smith J, Ting A, Wensley A, Yeager M, Zimmer M, Jirousek MR. Vu CB, et al. Among authors: jirousek mr. J Med Chem. 2016 Feb 11;59(3):1217-31. doi: 10.1021/acs.jmedchem.5b01961. Epub 2016 Feb 1. J Med Chem. 2016. PMID: 26784936
Discovery of imidazo[1,2-b]thiazole derivatives as novel SIRT1 activators.
Vu CB, Bemis JE, Disch JS, Ng PY, Nunes JJ, Milne JC, Carney DP, Lynch AV, Smith JJ, Lavu S, Lambert PD, Gagne DJ, Jirousek MR, Schenk S, Olefsky JM, Perni RB. Vu CB, et al. Among authors: jirousek mr. J Med Chem. 2009 Mar 12;52(5):1275-83. doi: 10.1021/jm8012954. J Med Chem. 2009. PMID: 19199480
CAT-2003: A novel sterol regulatory element-binding protein inhibitor that reduces steatohepatitis, plasma lipids, and atherosclerosis in apolipoprotein E*3-Leiden mice.
Zimmer M, Bista P, Benson EL, Lee DY, Liu F, Picarella D, Vega RB, Vu CB, Yeager M, Ding M, Liang G, Horton JD, Kleemann R, Kooistra T, Morrison MC, Wielinga PY, Milne JC, Jirousek MR, Nichols AJ. Zimmer M, et al. Among authors: jirousek mr. Hepatol Commun. 2017 May 12;1(4):311-325. doi: 10.1002/hep4.1042. eCollection 2017 Jun. Hepatol Commun. 2017. PMID: 29404461 Free PMC article.
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes.
Milne JC, Lambert PD, Schenk S, Carney DP, Smith JJ, Gagne DJ, Jin L, Boss O, Perni RB, Vu CB, Bemis JE, Xie R, Disch JS, Ng PY, Nunes JJ, Lynch AV, Yang H, Galonek H, Israelian K, Choy W, Iffland A, Lavu S, Medvedik O, Sinclair DA, Olefsky JM, Jirousek MR, Elliott PJ, Westphal CH. Milne JC, et al. Among authors: jirousek mr. Nature. 2007 Nov 29;450(7170):712-6. doi: 10.1038/nature06261. Nature. 2007. PMID: 18046409 Free PMC article.
Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo.
Smith JJ, Kenney RD, Gagne DJ, Frushour BP, Ladd W, Galonek HL, Israelian K, Song J, Razvadauskaite G, Lynch AV, Carney DP, Johnson RJ, Lavu S, Iffland A, Elliott PJ, Lambert PD, Elliston KO, Jirousek MR, Milne JC, Boss O. Smith JJ, et al. Among authors: jirousek mr. BMC Syst Biol. 2009 Mar 10;3:31. doi: 10.1186/1752-0509-3-31. BMC Syst Biol. 2009. PMID: 19284563 Free PMC article.
48 results