Meijer L - Search Results

1

Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1.

Llona-Minguez S, Höglund A, Jacques SA, Johansson L, Calderón-Montaño JM, Claesson M, Loseva O, Valerie NCK, Lundbäck T, Piedrafita J, Maga G, Crespan E, Meijer L, Morón EB, Baranczewski P, Hagbjörk AL, Svensson R, Wiita E, Almlöf I, Visnes T, Jeppsson F, Sigmundsson K, Jensen AJ, Artursson P, Jemth AS, Stenmark P, Berglund UW, Scobie M, Helleday T. Llona-Minguez S, et al. Among authors: meijer l. J Med Chem. 2016 Feb 11;59(3):1140-1148. doi: 10.1021/acs.jmedchem.5b01741. Epub 2016 Jan 27. J Med Chem. 2016. PMID: 26771665 Free PMC article.

2

Aloisines, a new family of CDK/GSK-3 inhibitors. SAR study, crystal structure in complex with CDK2, enzyme selectivity, and cellular effects.

Mettey Y, Gompel M, Thomas V, Garnier M, Leost M, Ceballos-Picot I, Noble M, Endicott J, Vierfond JM, Meijer L. Mettey Y, et al. Among authors: meijer l. J Med Chem. 2003 Jan 16;46(2):222-36. doi: 10.1021/jm020319p. J Med Chem. 2003. PMID: 12519061

3

Evaluation of the first cytostatically active 1-aza-9-oxafluorenes as novel selective CDK1 inhibitors with P-glycoprotein modulating properties.

Brachwitz K, Voigt B, Meijer L, Lozach O, Schächtele C, Molnár J, Hilgeroth A. Brachwitz K, et al. Among authors: meijer l. J Med Chem. 2003 Feb 27;46(5):876-9. doi: 10.1021/jm021090g. J Med Chem. 2003. PMID: 12593668

4

Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases.

Polychronopoulos P, Magiatis P, Skaltsounis AL, Myrianthopoulos V, Mikros E, Tarricone A, Musacchio A, Roe SM, Pearl L, Leost M, Greengard P, Meijer L. Polychronopoulos P, et al. Among authors: meijer l. J Med Chem. 2004 Feb 12;47(4):935-46. doi: 10.1021/jm031016d. J Med Chem. 2004. PMID: 14761195

5

Meridianins, a new family of protein kinase inhibitors isolated from the ascidian Aplidium meridianum.

Gompel M, Leost M, De Kier Joffe EB, Puricelli L, Franco LH, Palermo J, Meijer L. Gompel M, et al. Among authors: meijer l. Bioorg Med Chem Lett. 2004 Apr 5;14(7):1703-7. doi: 10.1016/j.bmcl.2004.01.050. Bioorg Med Chem Lett. 2004. PMID: 15026054

6

Synthesis of 3-substituted-2-oxoindole analogues and their evaluation as kinase inhibitors, anticancer and antiangiogenic agents.

Abadi AH, Abou-Seri SM, Abdel-Rahman DE, Klein C, Lozach O, Meijer L. Abadi AH, et al. Among authors: meijer l. Eur J Med Chem. 2006 Mar;41(3):296-305. doi: 10.1016/j.ejmech.2005.12.004. Epub 2006 Feb 21. Eur J Med Chem. 2006. PMID: 16494969

7

An integrated computational approach to the phenomenon of potent and selective inhibition of aurora kinases B and C by a series of 7-substituted indirubins.

Myrianthopoulos V, Magiatis P, Ferandin Y, Skaltsounis AL, Meijer L, Mikros E. Myrianthopoulos V, et al. Among authors: meijer l. J Med Chem. 2007 Aug 23;50(17):4027-37. doi: 10.1021/jm070077z. Epub 2007 Aug 1. J Med Chem. 2007. PMID: 17665890

8

Leucettines, a class of potent inhibitors of cdc2-like kinases and dual specificity, tyrosine phosphorylation regulated kinases derived from the marine sponge leucettamine B: modulation of alternative pre-RNA splicing.

Debdab M, Carreaux F, Renault S, Soundararajan M, Fedorov O, Filippakopoulos P, Lozach O, Babault L, Tahtouh T, Baratte B, Ogawa Y, Hagiwara M, Eisenreich A, Rauch U, Knapp S, Meijer L, Bazureau JP. Debdab M, et al. Among authors: meijer l. J Med Chem. 2011 Jun 23;54(12):4172-86. doi: 10.1021/jm200274d. Epub 2011 May 26. J Med Chem. 2011. PMID: 21615147

9

Synthesis, protein kinase inhibitory potencies, and in vitro antiproliferative activities of meridianin derivatives.

Giraud F, Alves G, Debiton E, Nauton L, Théry V, Durieu E, Ferandin Y, Lozach O, Meijer L, Anizon F, Pereira E, Moreau P. Giraud F, et al. Among authors: meijer l. J Med Chem. 2011 Jul 14;54(13):4474-89. doi: 10.1021/jm200464w. Epub 2011 Jun 10. J Med Chem. 2011. PMID: 21623630

10

Synthesis and biological evaluation of new 3-(6-hydroxyindol-2-yl)-5-(Phenyl) pyridine or pyrazine V-Shaped molecules as kinase inhibitors and cytotoxic agents.

Kassis P, Brzeszcz J, Bénéteau V, Lozach O, Meijer L, Le Guével R, Guillouzo C, Lewiński K, Bourg S, Colliandre L, Routier S, Mérour JY. Kassis P, et al. Among authors: meijer l. Eur J Med Chem. 2011 Nov;46(11):5416-34. doi: 10.1016/j.ejmech.2011.08.048. Epub 2011 Sep 8. Eur J Med Chem. 2011. PMID: 21944287

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