Castell JV - Search Results

1

Extending metabolome coverage for untargeted metabolite profiling of adherent cultured hepatic cells.

García-Cañaveras JC, López S, Castell JV, Donato MT, Lahoz A. García-Cañaveras JC, et al. Among authors: castell jv. Anal Bioanal Chem. 2016 Feb;408(4):1217-30. doi: 10.1007/s00216-015-9227-8. Epub 2016 Jan 14. Anal Bioanal Chem. 2016. PMID: 26769129

2

Validated assay for studying activity profiles of human liver UGTs after drug exposure: inhibition and induction studies.

Donato MT, Montero S, Castell JV, Gómez-Lechón MJ, Lahoz A. Donato MT, et al. Among authors: castell jv. Anal Bioanal Chem. 2010 Mar;396(6):2251-63. doi: 10.1007/s00216-009-3441-1. Epub 2010 Feb 10. Anal Bioanal Chem. 2010. PMID: 20145913

3

A comprehensive untargeted metabonomic analysis of human steatotic liver tissue by RP and HILIC chromatography coupled to mass spectrometry reveals important metabolic alterations.

García-Cañaveras JC, Donato MT, Castell JV, Lahoz A. García-Cañaveras JC, et al. Among authors: castell jv. J Proteome Res. 2011 Oct 7;10(10):4825-34. doi: 10.1021/pr200629p. Epub 2011 Sep 6. J Proteome Res. 2011. PMID: 21830829

4

Targeted profiling of circulating and hepatic bile acids in human, mouse, and rat using a UPLC-MRM-MS-validated method.

García-Cañaveras JC, Donato MT, Castell JV, Lahoz A. García-Cañaveras JC, et al. Among authors: castell jv. J Lipid Res. 2012 Oct;53(10):2231-2241. doi: 10.1194/jlr.D028803. Epub 2012 Jul 19. J Lipid Res. 2012. PMID: 22822028 Free PMC article.

5

A metabolomics cell-based approach for anticipating and investigating drug-induced liver injury.

García-Cañaveras JC, Castell JV, Donato MT, Lahoz A. García-Cañaveras JC, et al. Among authors: castell jv. Sci Rep. 2016 Jun 6;6:27239. doi: 10.1038/srep27239. Sci Rep. 2016. PMID: 27265840 Free PMC article.

6

A new in vitro approach for the simultaneous determination of phase I and phase II enzymatic activities of human hepatocyte preparations.

Lahoz A, Donato MT, Montero S, Castell JV, Gómez-Lechón MJ. Lahoz A, et al. Among authors: castell jv. Rapid Commun Mass Spectrom. 2008;22(2):240-4. doi: 10.1002/rcm.3359. Rapid Commun Mass Spectrom. 2008. PMID: 18088071

7

Identification of apoptotic drugs: multiparametric evaluation in cultured hepatocytes.

Gómez-Lechón MJ, O'Connor JE, Lahoz A, Castell JV, Donato MT. Gómez-Lechón MJ, et al. Among authors: castell jv. Curr Med Chem. 2008;15(20):2071-85. doi: 10.2174/092986708785132861. Curr Med Chem. 2008. PMID: 18691057 Review.

8

Evaluation of drug-metabolizing and functional competence of human hepatocytes incubated under hypothermia in different media for clinical infusion.

Gómez-Lechón MJ, Lahoz A, Jiménez N, Bonora A, Castell JV, Donato MT. Gómez-Lechón MJ, et al. Among authors: castell jv. Cell Transplant. 2008;17(8):887-97. doi: 10.3727/096368908786576534. Cell Transplant. 2008. PMID: 19069632 Free article.

9

Assessment of cytochrome P450 induction in human hepatocytes using the cocktail strategy plus liquid chromatography tandem mass spectrometry.

Lahoz A, Donato MT, Picazo L, Castell JV, Gómez-Lechón MJ. Lahoz A, et al. Among authors: castell jv. Drug Metab Lett. 2008 Aug;2(3):205-9. doi: 10.2174/187231208785425845. Drug Metab Lett. 2008. PMID: 19356095

10

Metabolite formation kinetics and intrinsic clearance of phenacetin, tolbutamide, alprazolam, and midazolam in adenoviral cytochrome P450-transfected HepG2 cells and comparison with hepatocytes and in vivo.

Donato MT, Hallifax D, Picazo L, Castell JV, Houston JB, Gomez-Lechón MJ, Lahoz A. Donato MT, et al. Among authors: castell jv. Drug Metab Dispos. 2010 Sep;38(9):1449-55. doi: 10.1124/dmd.110.033605. Epub 2010 May 25. Drug Metab Dispos. 2010. PMID: 20501911

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