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Page 1
Arylpiperidines as a new class of oxidosqualene cyclase inhibitors.
Keller M, Wolfgardt A, Müller C, Wilcken R, Böckler FM, Oliaro-Bosso S, Ferrante T, Balliano G, Bracher F. Keller M, et al. Among authors: wilcken r. Eur J Med Chem. 2016 Feb 15;109:13-22. doi: 10.1016/j.ejmech.2015.12.025. Epub 2015 Dec 17. Eur J Med Chem. 2016. PMID: 26745812 Free article.
Discovery and Optimization of Novel SUCNR1 Inhibitors: Design of Zwitterionic Derivatives with a Salt Bridge for the Improvement of Oral Exposure.
Velcicky J, Wilcken R, Cotesta S, Janser P, Schlapbach A, Wagner T, Piechon P, Villard F, Bouhelal R, Piller F, Harlfinger S, Stringer R, Fehlmann D, Kaupmann K, Littlewood-Evans A, Haffke M, Gommermann N. Velcicky J, et al. Among authors: wilcken r. J Med Chem. 2020 Sep 10;63(17):9856-9875. doi: 10.1021/acs.jmedchem.0c01020. Epub 2020 Aug 28. J Med Chem. 2020. PMID: 32856916
Lithocholic acid is an endogenous inhibitor of MDM4 and MDM2.
Vogel SM, Bauer MR, Joerger AC, Wilcken R, Brandt T, Veprintsev DB, Rutherford TJ, Fersht AR, Boeckler FM. Vogel SM, et al. Among authors: wilcken r. Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):16906-10. doi: 10.1073/pnas.1215060109. Epub 2012 Oct 3. Proc Natl Acad Sci U S A. 2012. PMID: 23035244 Free PMC article.
Discovery of novel pyrrolidineoxy-substituted heteroaromatics as potent and selective PI3K delta inhibitors with improved physicochemical properties.
Hoegenauer K, Soldermann N, Hebach C, Hollingworth GJ, Lewis I, von Matt A, Smith AB, Wolf RM, Wilcken R, Haasen D, Burkhart C, Zécri F. Hoegenauer K, et al. Among authors: wilcken r. Bioorg Med Chem Lett. 2016 Dec 1;26(23):5657-5662. doi: 10.1016/j.bmcl.2016.10.069. Epub 2016 Oct 27. Bioorg Med Chem Lett. 2016. PMID: 27816514
Small molecule induced reactivation of mutant p53 in cancer cells.
Liu X, Wilcken R, Joerger AC, Chuckowree IS, Amin J, Spencer J, Fersht AR. Liu X, et al. Among authors: wilcken r. Nucleic Acids Res. 2013 Jul;41(12):6034-44. doi: 10.1093/nar/gkt305. Epub 2013 Apr 29. Nucleic Acids Res. 2013. PMID: 23630318 Free PMC article.
Tracing the evolution of the p53 tetramerization domain.
Joerger AC, Wilcken R, Andreeva A. Joerger AC, et al. Among authors: wilcken r. Structure. 2014 Sep 2;22(9):1301-1310. doi: 10.1016/j.str.2014.07.010. Structure. 2014. PMID: 25185827 Free PMC article.
32 results