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A selective peroxisome proliferator-activated receptor δ agonist PYPEP suppresses atherosclerosis in association with improvement of the serum lipoprotein profiles in human apolipoprotein B100 and cholesteryl ester transfer protein double transgenic mice.
Naya N, Fukao K, Nakamura A, Hamada T, Sugimoto M, Kojima M, Yoshimura N, Uwabe K, Imagawa K, Nomura K, Hara S, Nakano T, Iwasaki T, Shinosaki T, Hanasaki K. Naya N, et al. Among authors: nakano t. Metabolism. 2016 Jan;65(1):16-25. doi: 10.1016/j.metabol.2015.09.016. Epub 2015 Sep 25. Metabolism. 2016. PMID: 26683793
Conformational restriction approach to β-secretase (BACE1) inhibitors: effect of a cyclopropane ring to induce an alternative binding mode.
Yonezawa S, Yamamoto T, Yamakawa H, Muto C, Hosono M, Hattori K, Higashino K, Yutsudo T, Iwamoto H, Kondo Y, Sakagami M, Togame H, Tanaka Y, Nakano T, Takemoto H, Arisawa M, Shuto S. Yonezawa S, et al. Among authors: nakano t. J Med Chem. 2012 Oct 25;55(20):8838-58. doi: 10.1021/jm3011405. Epub 2012 Oct 8. J Med Chem. 2012. PMID: 22998419
Conformational restriction approach to β-secretase (BACE1) inhibitors III: effective investigation of the binding mode by combinational use of X-ray analysis, isothermal titration calorimetry and theoretical calculations.
Yonezawa S, Fujiwara K, Yamamoto T, Hattori K, Yamakawa H, Muto C, Hosono M, Tanaka Y, Nakano T, Takemoto H, Arisawa M, Shuto S. Yonezawa S, et al. Among authors: nakano t. Bioorg Med Chem. 2013 Nov 1;21(21):6506-22. doi: 10.1016/j.bmc.2013.08.036. Epub 2013 Aug 28. Bioorg Med Chem. 2013. PMID: 24051074
Conformational restriction approach to BACE1 inhibitors II: SAR study of the isocytosine derivatives fixed with a cis-cyclopropane ring.
Yonezawa S, Yamakawa H, Muto C, Hosono M, Yamamoto T, Hattori K, Sakagami M, Togame H, Tanaka Y, Nakano T, Takemoto H, Arisawa M, Shuto S. Yonezawa S, et al. Among authors: nakano t. Bioorg Med Chem Lett. 2013 May 15;23(10):2912-5. doi: 10.1016/j.bmcl.2013.03.056. Epub 2013 Mar 26. Bioorg Med Chem Lett. 2013. PMID: 23562056
5,475 results