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Discovery of a potent and selective free fatty acid receptor 1 agonist with low lipophilicity and high oral bioavailability.
Christiansen E, Due-Hansen ME, Urban C, Grundmann M, Schmidt J, Hansen SV, Hudson BD, Zaibi M, Markussen SB, Hagesaether E, Milligan G, Cawthorne MA, Kostenis E, Kassack MU, Ulven T. Christiansen E, et al. Among authors: due hansen me. J Med Chem. 2013 Feb 14;56(3):982-92. doi: 10.1021/jm301470a. Epub 2013 Jan 22. J Med Chem. 2013. PMID: 23294321
Discovery of a Potent Free Fatty Acid 1 Receptor Agonist with Low Lipophilicity, Low Polar Surface Area, and Robust in Vivo Efficacy.
Hansen SV, Christiansen E, Urban C, Hudson BD, Stocker CJ, Due-Hansen ME, Wargent ET, Shimpukade B, Almeida R, Ejsing CS, Cawthorne MA, Kassack MU, Milligan G, Ulven T. Hansen SV, et al. Among authors: due hansen me. J Med Chem. 2016 Mar 24;59(6):2841-6. doi: 10.1021/acs.jmedchem.5b01962. Epub 2016 Mar 15. J Med Chem. 2016. PMID: 26928019
Structure-Activity Study of Dihydrocinnamic Acids and Discovery of the Potent FFA1 (GPR40) Agonist TUG-469.
Christiansen E, Due-Hansen ME, Urban C, Merten N, Pfleiderer M, Karlsen KK, Rasmussen SS, Steensgaard M, Hamacher A, Schmidt J, Drewke C, Petersen RK, Kristiansen K, Ullrich S, Kostenis E, Kassack MU, Ulven T. Christiansen E, et al. ACS Med Chem Lett. 2010 Jul 2;1(7):345-9. doi: 10.1021/ml100106c. eCollection 2010 Oct 14. ACS Med Chem Lett. 2010. PMID: 24900217 Free PMC article.
Defining the molecular basis for the first potent and selective orthosteric agonists of the FFA2 free fatty acid receptor.
Hudson BD, Due-Hansen ME, Christiansen E, Hansen AM, Mackenzie AE, Murdoch H, Pandey SK, Ward RJ, Marquez R, Tikhonova IG, Ulven T, Milligan G. Hudson BD, et al. Among authors: due hansen me. J Biol Chem. 2013 Jun 14;288(24):17296-312. doi: 10.1074/jbc.M113.455337. Epub 2013 Apr 15. J Biol Chem. 2013. PMID: 23589301 Free PMC article.
Mucus can change the permeation rank order of drug candidates.
Hagesaether E, Christiansen E, Due-Hansen ME, Ulven T. Hagesaether E, et al. Among authors: due hansen me. Int J Pharm. 2013 Aug 16;452(1-2):276-82. doi: 10.1016/j.ijpharm.2013.05.036. Epub 2013 May 23. Int J Pharm. 2013. PMID: 23707884
12 results