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Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH.
Science. 2015 Dec 11;350(6266):1391-6. doi: 10.1126/science.aaa5004. Epub 2015 Nov 5.
Science. 2015.
PMID: 26541605
Free PMC article.
Deletion of the gene Pip4k2c, a novel phosphatidylinositol kinase, results in hyperactivation of the immune system.
Shim H, Wu C, Ramsamooj S, Bosch KN, Chen Z, Emerling BM, Yun J, Liu H, Choo-Wing R, Yang Z, Wulf GM, Kuchroo VK, Cantley LC.
Shim H, et al. Among authors: bosch kn.
Proc Natl Acad Sci U S A. 2016 Jul 5;113(27):7596-601. doi: 10.1073/pnas.1600934113. Epub 2016 Jun 16.
Proc Natl Acad Sci U S A. 2016.
PMID: 27313209
Free PMC article.
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High-fructose corn syrup enhances intestinal tumor growth in mice.
Goncalves MD, Lu C, Tutnauer J, Hartman TE, Hwang SK, Murphy CJ, Pauli C, Morris R, Taylor S, Bosch K, Yang S, Wang Y, Van Riper J, Lekaye HC, Roper J, Kim Y, Chen Q, Gross SS, Rhee KY, Cantley LC, Yun J.
Goncalves MD, et al.
Science. 2019 Mar 22;363(6433):1345-1349. doi: 10.1126/science.aat8515.
Science. 2019.
PMID: 30898933
Free PMC article.
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A local tumor microenvironment acquired super-enhancer induces an oncogenic driver in colorectal carcinoma.
Zhou RW, Xu J, Martin TC, Zachem AL, He J, Ozturk S, Demircioglu D, Bansal A, Trotta AP, Giotti B, Gryder B, Shen Y, Wu X, Carcamo S, Bosch K, Hopkins B, Tsankov A, Steinhagen R, Jones DR, Asara J, Chipuk JE, Brody R, Itzkowitz S, Chio IIC, Hasson D, Bernstein E, Parsons RE.
Zhou RW, et al.
Nat Commun. 2022 Oct 17;13(1):6041. doi: 10.1038/s41467-022-33377-8.
Nat Commun. 2022.
PMID: 36253360
Free PMC article.
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Author Correction: A local tumor microenvironment acquired super-enhancer induces an oncogenic driver in colorectal carcinoma.
Zhou RW, Xu J, Martin TC, Zachem AL, He J, Ozturk S, Demircioglu D, Bansal A, Trotta AP, Giotti B, Gryder B, Shen Y, Wu X, Carcamo S, Bosch K, Hopkins B, Tsankov A, Steinhagen R, Jones DR, Asara J, Chipuk JE, Brody R, Itzkowitz S, Chio IIC, Hasson D, Bernstein E, Parsons RE.
Zhou RW, et al.
Nat Commun. 2023 Apr 6;14(1):1923. doi: 10.1038/s41467-023-37640-4.
Nat Commun. 2023.
PMID: 37024505
Free PMC article.
No abstract available.
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AKT activation because of PTEN loss upregulates xCT via GSK3β/NRF2, leading to inhibition of ferroptosis in PTEN-mutant tumor cells.
Cahuzac KM, Lubin A, Bosch K, Stokes N, Shoenfeld SM, Zhou R, Lemon H, Asara J, Parsons RE.
Cahuzac KM, et al.
Cell Rep. 2023 May 30;42(5):112536. doi: 10.1016/j.celrep.2023.112536. Epub 2023 May 20.
Cell Rep. 2023.
PMID: 37210723
Free PMC article.
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