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TRV0109101, a G Protein-Biased Agonist of the µ-Opioid Receptor, Does Not Promote Opioid-Induced Mechanical Allodynia following Chronic Administration.
J Pharmacol Exp Ther. 2017 Aug;362(2):254-262. doi: 10.1124/jpet.117.241117. Epub 2017 May 22.
J Pharmacol Exp Ther. 2017.
PMID: 28533287
Biased mu-opioid receptor ligands: a promising new generation of pain therapeutics.
Siuda ER, Carr R 3rd, Rominger DH, Violin JD.
Siuda ER, et al. Among authors: carr r 3rd.
Curr Opin Pharmacol. 2017 Feb;32:77-84. doi: 10.1016/j.coph.2016.11.007. Epub 2016 Dec 7.
Curr Opin Pharmacol. 2017.
PMID: 27936408
Review.
Item in Clipboard
β-arrestin-biased signaling through the β2-adrenergic receptor promotes cardiomyocyte contraction.
Carr R 3rd, Schilling J, Song J, Carter RL, Du Y, Yoo SM, Traynham CJ, Koch WJ, Cheung JY, Tilley DG, Benovic JL.
Carr R 3rd, et al.
Proc Natl Acad Sci U S A. 2016 Jul 12;113(28):E4107-16. doi: 10.1073/pnas.1606267113. Epub 2016 Jun 27.
Proc Natl Acad Sci U S A. 2016.
PMID: 27354517
Free PMC article.
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From biased signalling to polypharmacology: unlocking unique intracellular signalling using pepducins.
Carr R 3rd, Benovic JL.
Carr R 3rd, et al.
Biochem Soc Trans. 2016 Apr 15;44(2):555-61. doi: 10.1042/BST20150230.
Biochem Soc Trans. 2016.
PMID: 27068969
Review.
Item in Clipboard
Interdicting Gq Activation in Airway Disease by Receptor-Dependent and Receptor-Independent Mechanisms.
Carr R 3rd, Koziol-White C, Zhang J, Lam H, An SS, Tall GG, Panettieri RA Jr, Benovic JL.
Carr R 3rd, et al.
Mol Pharmacol. 2016 Jan;89(1):94-104. doi: 10.1124/mol.115.100339. Epub 2015 Oct 13.
Mol Pharmacol. 2016.
PMID: 26464325
Free PMC article.
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Consequence of the tumor-associated conversion to cyclin D1b.
Augello MA, Berman-Booty LD, Carr R 3rd, Yoshida A, Dean JL, Schiewer MJ, Feng FY, Tomlins SA, Gao E, Koch WJ, Benovic JL, Diehl JA, Knudsen KE.
Augello MA, et al. Among authors: carr r 3rd.
EMBO Mol Med. 2015 May;7(5):628-47. doi: 10.15252/emmm.201404242.
EMBO Mol Med. 2015.
PMID: 25787974
Free PMC article.
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Development and characterization of pepducins as Gs-biased allosteric agonists.
Carr R 3rd, Du Y, Quoyer J, Panettieri RA Jr, Janz JM, Bouvier M, Kobilka BK, Benovic JL.
Carr R 3rd, et al.
J Biol Chem. 2014 Dec 26;289(52):35668-84. doi: 10.1074/jbc.M114.618819. Epub 2014 Nov 13.
J Biol Chem. 2014.
PMID: 25395624
Free PMC article.
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