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6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Regioisomers as Targeted Antifolates for Folate Receptor α and the Proton-Coupled Folate Transporter in Human Tumors.
Wang L, Wallace A, Raghavan S, Deis SM, Wilson MR, Yang S, Polin L, White K, Kushner J, Orr S, George C, O'Connor C, Hou Z, Mitchell-Ryan S, Dann CE 3rd, Matherly LH, Gangjee A. Wang L, et al. Among authors: kushner j. J Med Chem. 2015 Sep 10;58(17):6938-59. doi: 10.1021/acs.jmedchem.5b00801. Epub 2015 Aug 28. J Med Chem. 2015. PMID: 26317331 Free PMC article.
Discovery of cryptophycin-1 and BCN-183577: examples of strategies and problems in the detection of antitumor activity in mice.
Corbett TH, Valeriote FA, Demchik L, Lowichik N, Polin L, Panchapor C, Pugh S, White K, Kushner J, Rake J, Wentland M, Golakoti T, Hetzel C, Ogino J, Patterson G, Moore R. Corbett TH, et al. Among authors: kushner j. Invest New Drugs. 1997;15(3):207-18. doi: 10.1023/a:1005875015011. Invest New Drugs. 1997. PMID: 9387043 Review.
Preclinical efficacy of thioxanthone SR271425 against transplanted solid tumors of mouse and human origin.
Corbett TH, Panchapor C, Polin L, Lowichik N, Pugh S, White K, Kushner J, Meyer J, Czarnecki J, Chinnukroh S, Edelstein M, LoRusso P, Heilbrun L, Horwitz JP, Grieshaber C, Perni R, Wentland M, Coughlin S, Elenbaas S, Philion R, Rake J. Corbett TH, et al. Among authors: kushner j. Invest New Drugs. 1999;17(1):17-27. doi: 10.1023/a:1006267517726. Invest New Drugs. 1999. PMID: 10555119
II. Synthesis and biological evaluation of some bioisosteres and congeners of the antitumor agent, 2-(4-[(7-chloro-2-quinoxalinyl)oxy]phenoxy)propionic acid (XK469).
Hazeldine ST, Polin L, Kushner J, White K, Bouregeois NM, Crantz B, Palomino E, Corbett TH, Horwitz JP. Hazeldine ST, et al. Among authors: kushner j. J Med Chem. 2002 Jul 4;45(14):3130-7. doi: 10.1021/jm0200097. J Med Chem. 2002. PMID: 12086498
The synthetic approach to each of the bioisosteres of 1 utilized the methodology developed in previous work (see Hazeldine, S. T.; Polin, L.; Kushner, J.; Paluch, J.; White, K.; Edelstein, M.; Palomino, E.; Corbett, T. H.; Horwitz, J. P. Design, Synthe …
The synthetic approach to each of the bioisosteres of 1 utilized the methodology developed in previous work (see Hazeldine, S. T.; Polin, L. …
432 results