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Limiting replication stress during somatic cell reprogramming reduces genomic instability in induced pluripotent stem cells.
Ruiz S, Lopez-Contreras AJ, Gabut M, Marion RM, Gutierrez-Martinez P, Bua S, Ramirez O, Olalde I, Rodrigo-Perez S, Li H, Marques-Bonet T, Serrano M, Blasco MA, Batada NN, Fernandez-Capetillo O. Ruiz S, et al. Among authors: li h. Nat Commun. 2015 Aug 21;6:8036. doi: 10.1038/ncomms9036. Nat Commun. 2015. PMID: 26292731 Free PMC article.
The Ink4/Arf locus is a barrier for iPS cell reprogramming.
Li H, Collado M, Villasante A, Strati K, Ortega S, Cañamero M, Blasco MA, Serrano M. Li H, et al. Nature. 2009 Aug 27;460(7259):1136-9. doi: 10.1038/nature08290. Epub 2009 Aug 9. Nature. 2009. PMID: 19668188 Free PMC article.
p27(Kip1) directly represses Sox2 during embryonic stem cell differentiation.
Li H, Collado M, Villasante A, Matheu A, Lynch CJ, Cañamero M, Rizzoti K, Carneiro C, Martínez G, Vidal A, Lovell-Badge R, Serrano M. Li H, et al. Cell Stem Cell. 2012 Dec 7;11(6):845-52. doi: 10.1016/j.stem.2012.09.014. Cell Stem Cell. 2012. PMID: 23217425 Free PMC article.
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