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Stem cells act through multiple mechanisms to benefit mice with neurodegenerative metabolic disease.
Lee JP, Jeyakumar M, Gonzalez R, Takahashi H, Lee PJ, Baek RC, Clark D, Rose H, Fu G, Clarke J, McKercher S, Meerloo J, Muller FJ, Park KI, Butters TD, Dwek RA, Schwartz P, Tong G, Wenger D, Lipton SA, Seyfried TN, Platt FM, Snyder EY. Lee JP, et al. Among authors: lipton sa. Nat Med. 2007 Apr;13(4):439-47. doi: 10.1038/nm1548. Epub 2007 Mar 11. Nat Med. 2007. PMID: 17351625
Carnosic acid, a catechol-type electrophilic compound, protects neurons both in vitro and in vivo through activation of the Keap1/Nrf2 pathway via S-alkylation of targeted cysteines on Keap1.
Satoh T, Kosaka K, Itoh K, Kobayashi A, Yamamoto M, Shimojo Y, Kitajima C, Cui J, Kamins J, Okamoto S, Izumi M, Shirasawa T, Lipton SA. Satoh T, et al. Among authors: lipton sa. J Neurochem. 2008 Feb;104(4):1116-31. doi: 10.1111/j.1471-4159.2007.05039.x. Epub 2007 Nov 6. J Neurochem. 2008. PMID: 17995931 Free PMC article.
Transcription factor MEF2C influences neural stem/progenitor cell differentiation and maturation in vivo.
Li H, Radford JC, Ragusa MJ, Shea KL, McKercher SR, Zaremba JD, Soussou W, Nie Z, Kang YJ, Nakanishi N, Okamoto S, Roberts AJ, Schwarz JJ, Lipton SA. Li H, et al. Among authors: lipton sa. Proc Natl Acad Sci U S A. 2008 Jul 8;105(27):9397-402. doi: 10.1073/pnas.0802876105. Epub 2008 Jul 1. Proc Natl Acad Sci U S A. 2008. PMID: 18599437 Free PMC article.
Autistic phenotype from MEF2C knockout cells.
Lipton SA, Li H, Zaremba JD, McKercher SR, Cui J, Kang YJ, Nie Z, Soussou W, Talantova M, Okamoto S, Nakanishi N. Lipton SA, et al. Science. 2009 Jan 9;323(5911):208. doi: 10.1126/science.323.5911.208b. Science. 2009. PMID: 19131610 No abstract available.
474 results