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MutT homologue 1 (MTH1) catalyzes the hydrolysis of mutagenic O6-methyl-dGTP.
Jemth AS, Gustafsson R, Bräutigam L, Henriksson L, Vallin KSA, Sarno A, Almlöf I, Homan E, Rasti A, Warpman Berglund U, Stenmark P, Helleday T. Jemth AS, et al. Among authors: warpman berglund u. Nucleic Acids Res. 2018 Nov 16;46(20):10888-10904. doi: 10.1093/nar/gky896. Nucleic Acids Res. 2018. PMID: 30304478 Free PMC article.
MutT homologue 1 (MTH1) removes N6-methyl-dATP from the dNTP pool.
Scaletti ER, Vallin KS, Bräutigam L, Sarno A, Warpman Berglund U, Helleday T, Stenmark P, Jemth AS. Scaletti ER, et al. Among authors: warpman berglund u. J Biol Chem. 2020 Apr 10;295(15):4761-4772. doi: 10.1074/jbc.RA120.012636. Epub 2020 Mar 6. J Biol Chem. 2020. PMID: 32144205 Free PMC article.
Validation and development of MTH1 inhibitors for treatment of cancer.
Warpman Berglund U, Sanjiv K, Gad H, Kalderén C, Koolmeister T, Pham T, Gokturk C, Jafari R, Maddalo G, Seashore-Ludlow B, Chernobrovkin A, Manoilov A, Pateras IS, Rasti A, Jemth AS, Almlöf I, Loseva O, Visnes T, Einarsdottir BO, Gaugaz FZ, Saleh A, Platzack B, Wallner OA, Vallin KS, Henriksson M, Wakchaure P, Borhade S, Herr P, Kallberg Y, Baranczewski P, Homan EJ, Wiita E, Nagpal V, Meijer T, Schipper N, Rudd SG, Bräutigam L, Lindqvist A, Filppula A, Lee TC, Artursson P, Nilsson JA, Gorgoulis VG, Lehtiö J, Zubarev RA, Scobie M, Helleday T. Warpman Berglund U, et al. Ann Oncol. 2016 Dec;27(12):2275-2283. doi: 10.1093/annonc/mdw429. Epub 2016 Nov 8. Ann Oncol. 2016. PMID: 27827301 Free article.
Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies.
Herold N, Rudd SG, Ljungblad L, Sanjiv K, Myrberg IH, Paulin CB, Heshmati Y, Hagenkort A, Kutzner J, Page BD, Calderón-Montaño JM, Loseva O, Jemth AS, Bulli L, Axelsson H, Tesi B, Valerie NC, Höglund A, Bladh J, Wiita E, Sundin M, Uhlin M, Rassidakis G, Heyman M, Tamm KP, Warpman-Berglund U, Walfridsson J, Lehmann S, Grandér D, Lundbäck T, Kogner P, Henter JI, Helleday T, Schaller T. Herold N, et al. Among authors: warpman berglund u. Nat Med. 2017 Feb;23(2):256-263. doi: 10.1038/nm.4265. Epub 2017 Jan 9. Nat Med. 2017. PMID: 28067901
Piperazin-1-ylpyridazine Derivatives Are a Novel Class of Human dCTP Pyrophosphatase 1 Inhibitors.
Llona-Minguez S, Höglund A, Ghassemian A, Desroses M, Calderón-Montaño JM, Burgos Morón E, Valerie NCK, Wiita E, Almlöf I, Koolmeister T, Mateus A, Cazares-Körner C, Sanjiv K, Homan E, Loseva O, Baranczewski P, Darabi M, Mehdizadeh A, Fayezi S, Jemth AS, Warpman Berglund U, Sigmundsson K, Lundbäck T, Jenmalm Jensen A, Artursson P, Scobie M, Helleday T. Llona-Minguez S, et al. Among authors: warpman berglund u. J Med Chem. 2017 May 25;60(10):4279-4292. doi: 10.1021/acs.jmedchem.7b00182. Epub 2017 May 16. J Med Chem. 2017. PMID: 28508636
MTH1 Inhibitors for the Treatment of Psoriasis.
Bivik Eding C, Köhler I, Verma D, Sjögren F, Bamberg C, Karsten S, Pham T, Scobie M, Helleday T, Warpman Berglund U, Enerbäck C. Bivik Eding C, et al. Among authors: warpman berglund u. J Invest Dermatol. 2021 Aug;141(8):2037-2048.e4. doi: 10.1016/j.jid.2021.01.026. Epub 2021 Mar 5. J Invest Dermatol. 2021. PMID: 33676948 Free article.
31 results