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β-Catenin is required for intrinsic but not extrinsic BCR-ABL1 kinase-independent resistance to tyrosine kinase inhibitors in chronic myeloid leukemia.
Leukemia. 2015 Dec;29(12):2328-37. doi: 10.1038/leu.2015.196. Epub 2015 Jul 23.
Leukemia. 2015.
PMID: 26202934
Free PMC article.
shRNA library screening identifies nucleocytoplasmic transport as a mediator of BCR-ABL1 kinase-independent resistance.
Khorashad JS, Eiring AM, Mason CC, Gantz KC, Bowler AD, Redwine HM, Yu F, Kraft IL, Pomicter AD, Reynolds KR, Iovino AJ, Zabriskie MS, Heaton WL, Tantravahi SK, Kauffman M, Shacham S, Chenchik A, Bonneau K, Ullman KS, O'Hare T, Deininger MW.
Khorashad JS, et al. Among authors: bowler ad.
Blood. 2015 Mar 12;125(11):1772-81. doi: 10.1182/blood-2014-08-588855. Epub 2015 Jan 8.
Blood. 2015.
PMID: 25573989
Free PMC article.
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MS4A3 promotes differentiation in chronic myeloid leukemia by enhancing common β-chain cytokine receptor endocytosis.
Zhao H, Pomicter AD, Eiring AM, Franzini A, Ahmann J, Hwang JY, Senina A, Helton B, Iyer S, Yan D, Khorashad JS, Zabriskie MS, Agarwal A, Redwine HM, Bowler AD, Clair PM, McWeeney SK, Druker BJ, Tyner JW, Stirewalt DL, Oehler VG, Varambally S, Berrett KC, Vahrenkamp JM, Gertz J, Varley KE, Radich JP, Deininger MW.
Zhao H, et al. Among authors: bowler ad.
Blood. 2022 Feb 3;139(5):761-778. doi: 10.1182/blood.2021011802.
Blood. 2022.
PMID: 34780648
Free PMC article.
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Combining the Allosteric Inhibitor Asciminib with Ponatinib Suppresses Emergence of and Restores Efficacy against Highly Resistant BCR-ABL1 Mutants.
Eide CA, Zabriskie MS, Savage Stevens SL, Antelope O, Vellore NA, Than H, Schultz AR, Clair P, Bowler AD, Pomicter AD, Yan D, Senina AV, Qiang W, Kelley TW, Szankasi P, Heinrich MC, Tyner JW, Rea D, Cayuela JM, Kim DW, Tognon CE, O'Hare T, Druker BJ, Deininger MW.
Eide CA, et al. Among authors: bowler ad.
Cancer Cell. 2019 Oct 14;36(4):431-443.e5. doi: 10.1016/j.ccell.2019.08.004. Epub 2019 Sep 19.
Cancer Cell. 2019.
PMID: 31543464
Free PMC article.
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Spatiotemporally resolved colorectal oncogenesis in mini-colons ex vivo.
Lorenzo-Martín LF, Hübscher T, Bowler AD, Broguiere N, Langer J, Tillard L, Nikolaev M, Radtke F, Lutolf MP.
Lorenzo-Martín LF, et al. Among authors: bowler ad.
Nature. 2024 May;629(8011):450-457. doi: 10.1038/s41586-024-07330-2. Epub 2024 Apr 24.
Nature. 2024.
PMID: 38658753
Free PMC article.
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Bcl-xL targeting eliminates ageing tumor-promoting neutrophils and inhibits lung tumor growth.
Bodac A, Mayet A, Rana S, Pascual J, Bowler AD, Roh V, Fournier N, Craciun L, Demetter P, Radtke F, Meylan E.
Bodac A, et al. Among authors: bowler ad.
EMBO Mol Med. 2024 Jan;16(1):158-184. doi: 10.1038/s44321-023-00013-x. Epub 2023 Dec 20.
EMBO Mol Med. 2024.
PMID: 38177532
Free PMC article.
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Neutrophils suppress tumor-infiltrating T cells in colon cancer via matrix metalloproteinase-mediated activation of TGFβ.
Germann M, Zangger N, Sauvain MO, Sempoux C, Bowler AD, Wirapati P, Kandalaft LE, Delorenzi M, Tejpar S, Coukos G, Radtke F.
Germann M, et al. Among authors: bowler ad.
EMBO Mol Med. 2020 Jan 9;12(1):e10681. doi: 10.15252/emmm.201910681. Epub 2019 Dec 2.
EMBO Mol Med. 2020.
PMID: 31793740
Free PMC article.
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