New GABA modulators protect photoreceptor cells from light-induced degeneration in mouse models.
Schur RM, Gao S, Yu G, Chen Y, Maeda A, Palczewski K, Lu ZR.
Schur RM, et al. Among authors: maeda a.
FASEB J. 2018 Jun;32(6):3289-3300. doi: 10.1096/fj.201701250R. Epub 2018 Jan 24.
FASEB J. 2018.
PMID: 29401616
Free PMC article.
Imaging and functional assessments of the retina indicated that these compounds successfully protected photoreceptor cells from degeneration to maintain a full-visual-field response. Furthermore, these compounds demonstrated a strong safety profile in wild-type mice …
Imaging and functional assessments of the retina indicated that these compounds successfully protected photoreceptor cells from degeneration …