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Chemical Modification of a Dehydratase Enzyme Involved in Bacterial Virulence by an Ammonium Derivative: Evidence of its Active Site Covalent Adduct.
J Am Chem Soc. 2015 Jul 29;137(29):9333-43. doi: 10.1021/jacs.5b04080. Epub 2015 Jul 16.
J Am Chem Soc. 2015.
PMID: 26148116
Synthesis and biological evaluation of new nanomolar competitive inhibitors of Helicobacter pylori type II dehydroquinase. Structural details of the role of the aromatic moieties with essential residues.
Prazeres VF, Tizón L, Otero JM, Guardado-Calvo P, Llamas-Saiz AL, van Raaij MJ, Castedo L, Lamb H, Hawkins AR, González-Bello C.
Prazeres VF, et al. Among authors: tizon l.
J Med Chem. 2010 Jan 14;53(1):191-200. doi: 10.1021/jm9010466.
J Med Chem. 2010.
PMID: 19911771
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Understanding the key factors that control the inhibition of type II dehydroquinase by (2R)-2-benzyl-3-dehydroquinic acids.
Peón A, Otero JM, Tizón L, Prazeres VF, Llamas-Saiz AL, Fox GC, van Raaij MJ, Lamb H, Hawkins AR, Gago F, Castedo L, González-Bello C.
Peón A, et al. Among authors: tizon l.
ChemMedChem. 2010 Oct 4;5(10):1726-33. doi: 10.1002/cmdc.201000281.
ChemMedChem. 2010.
PMID: 20815012
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A prodrug approach for improving antituberculosis activity of potent Mycobacterium tuberculosis type II dehydroquinase inhibitors.
Tizón L, Otero JM, Prazeres VF, Llamas-Saiz AL, Fox GC, van Raaij MJ, Lamb H, Hawkins AR, Ainsa JA, Castedo L, González-Bello C.
Tizón L, et al.
J Med Chem. 2011 Sep 8;54(17):6063-84. doi: 10.1021/jm2006063. Epub 2011 Aug 3.
J Med Chem. 2011.
PMID: 21780742
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Mechanistic basis of the inhibition of type II dehydroquinase by (2S)- and (2R)-2-benzyl-3-dehydroquinic acids.
Lence E, Tizón L, Otero JM, Peón A, Prazeres VF, Llamas-Saiz AL, Fox GC, van Raaij MJ, Lamb H, Hawkins AR, González-Bello C.
Lence E, et al. Among authors: tizon l.
ACS Chem Biol. 2013 Mar 15;8(3):568-77. doi: 10.1021/cb300493s. Epub 2012 Dec 6.
ACS Chem Biol. 2013.
PMID: 23198883
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Irreversible covalent modification of type I dehydroquinase with a stable Schiff base.
Tizón L, Maneiro M, Peón A, Otero JM, Lence E, Poza S, van Raaij MJ, Thompson P, Hawkins AR, González-Bello C.
Tizón L, et al.
Org Biomol Chem. 2015 Jan 21;13(3):706-16. doi: 10.1039/c4ob01782j.
Org Biomol Chem. 2015.
PMID: 25370445
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Tetrahydrobenzothiophene derivatives: conformationally restricted inhibitors of type II dehydroquinase.
Paz S, Tizón L, Otero JM, Llamas-Saiz AL, Fox GC, van Raaij MJ, Lamb H, Hawkins AR, Lapthorn AJ, Castedo L, González-Bello C.
Paz S, et al. Among authors: tizon l.
ChemMedChem. 2011 Feb 7;6(2):266-72. doi: 10.1002/cmdc.201000343. Epub 2010 Nov 10.
ChemMedChem. 2011.
PMID: 21275050
No abstract available.
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