Lead Exposure during Early Human Development and DNA Methylation of Imprinted Gene Regulatory Elements in Adulthood.
Li Y, Xie C, Murphy SK, Skaar D, Nye M, Vidal AC, Cecil KM, Dietrich KN, Puga A, Jirtle RL, Hoyo C.
Li Y, et al. Among authors: puga a.
Environ Health Perspect. 2016 May;124(5):666-73. doi: 10.1289/ehp.1408577. Epub 2015 Jun 26.
Environ Health Perspect. 2016.
PMID: 26115033
Free PMC article.
RESULTS: Mean blood lead concentration from birth to 78 months was associated with a significant decrease in PEG3 DMR methylation (beta = -0.0014; 95% CI: -0.0023, -0.0005, p = 0.002), stronger in males (beta = -0.0024; 95% CI: -0.0038, -0.0009, p = 0.003) than in females …
RESULTS: Mean blood lead concentration from birth to 78 months was associated with a significant decrease in PEG3 DMR methylation (be …