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Optimization of a novel series of N-phenylindoline-5-sulfonamide-based acyl CoA:monoacylglycerol acyltransferase-2 inhibitors: Mitigation of CYP3A4 time-dependent inhibition and phototoxic liabilities.
Sato K, Takahagi H, Kubo O, Hidaka K, Yoshikawa T, Kamaura M, Nakakariya M, Amano N, Adachi R, Maki T, Take K, Takekawa S, Kitazaki T, Maekawa T. Sato K, et al. Among authors: amano n. Bioorg Med Chem. 2015 Aug 1;23(15):4544-4560. doi: 10.1016/j.bmc.2015.06.003. Epub 2015 Jun 9. Bioorg Med Chem. 2015. PMID: 26100443
Discovery of a Novel Series of N-Phenylindoline-5-sulfonamide Derivatives as Potent, Selective, and Orally Bioavailable Acyl CoA:Monoacylglycerol Acyltransferase-2 Inhibitors.
Sato K, Takahagi H, Yoshikawa T, Morimoto S, Takai T, Hidaka K, Kamaura M, Kubo O, Adachi R, Ishii T, Maki T, Mochida T, Takekawa S, Nakakariya M, Amano N, Kitazaki T. Sato K, et al. Among authors: amano n. J Med Chem. 2015 May 14;58(9):3892-909. doi: 10.1021/acs.jmedchem.5b00178. Epub 2015 Apr 30. J Med Chem. 2015. PMID: 25897973
Highly potent antiobesity effect of a short-length peptide YY analog in mice.
Nishizawa N, Niida A, Adachi Y, Kanematsu-Yamaki Y, Masuda Y, Kumano S, Yokoyama K, Noguchi Y, Asakawa T, Hirabayashi H, Amano N, Takekawa S, Ohtaki T, Asami T. Nishizawa N, et al. Among authors: amano n. Bioorg Med Chem. 2017 Oct 15;25(20):5718-5725. doi: 10.1016/j.bmc.2017.08.044. Epub 2017 Sep 1. Bioorg Med Chem. 2017. PMID: 28917449
Symmetrical approach of spiro-pyrazolidinediones as acetyl-CoA carboxylase inhibitors.
Kamata M, Yamashita T, Kina A, Tawada M, Endo S, Mizukami A, Sasaki M, Tani A, Nakano Y, Watanabe Y, Furuyama N, Funami M, Amano N, Fukatsu K. Kamata M, et al. Among authors: amano n. Bioorg Med Chem Lett. 2012 Jul 15;22(14):4769-72. doi: 10.1016/j.bmcl.2012.05.062. Epub 2012 May 19. Bioorg Med Chem Lett. 2012. PMID: 22677317
Design and synthesis of a novel series of orally active, selective somatostatin receptor 2 agonists for the treatment of type 2 diabetes.
Banno Y, Sasaki S, Kamata M, Kunitomo J, Miyamoto Y, Abe H, Taya N, Oi S, Watanabe M, Urushibara T, Hazama M, Niwa SI, Miyamoto S, Horinouchi A, Kuroshima KI, Amano N, Matsumoto SI, Matsunaga S. Banno Y, et al. Among authors: amano n. Bioorg Med Chem. 2017 Nov 1;25(21):5995-6006. doi: 10.1016/j.bmc.2017.09.031. Epub 2017 Sep 21. Bioorg Med Chem. 2017. PMID: 28988629
397 results