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Leinamycin E1 acting as an anticancer prodrug activated by reactive oxygen species.
Huang SX, Yun BS, Ma M, Basu HS, Church DR, Ingenhorst G, Huang Y, Yang D, Lohman JR, Tang GL, Ju J, Liu T, Wilding G, Shen B. Huang SX, et al. Among authors: ma m. Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):8278-83. doi: 10.1073/pnas.1506761112. Epub 2015 Jun 8. Proc Natl Acad Sci U S A. 2015. PMID: 26056295 Free PMC article.
C-S bond cleavage by a polyketide synthase domain.
Ma M, Lohman JR, Liu T, Shen B. Ma M, et al. Proc Natl Acad Sci U S A. 2015 Aug 18;112(33):10359-64. doi: 10.1073/pnas.1508437112. Epub 2015 Aug 3. Proc Natl Acad Sci U S A. 2015. PMID: 26240335 Free PMC article.
Discovery of the leinamycin family of natural products by mining actinobacterial genomes.
Pan G, Xu Z, Guo Z, Hindra, Ma M, Yang D, Zhou H, Gansemans Y, Zhu X, Huang Y, Zhao LX, Jiang Y, Cheng J, Van Nieuwerburgh F, Suh JW, Duan Y, Shen B. Pan G, et al. Among authors: ma m. Proc Natl Acad Sci U S A. 2017 Dec 26;114(52):E11131-E11140. doi: 10.1073/pnas.1716245115. Epub 2017 Dec 11. Proc Natl Acad Sci U S A. 2017. PMID: 29229819 Free PMC article.
Structural and evolutionary relationships of "AT-less" type I polyketide synthase ketosynthases.
Lohman JR, Ma M, Osipiuk J, Nocek B, Kim Y, Chang C, Cuff M, Mack J, Bigelow L, Li H, Endres M, Babnigg G, Joachimiak A, Phillips GN Jr, Shen B. Lohman JR, et al. Among authors: ma m. Proc Natl Acad Sci U S A. 2015 Oct 13;112(41):12693-8. doi: 10.1073/pnas.1515460112. Epub 2015 Sep 29. Proc Natl Acad Sci U S A. 2015. PMID: 26420866 Free PMC article.
Germicidins H-J from Streptomyces sp. CB00361.
Ma M, Rateb ME, Yang D, Rudolf JD, Zhu X, Huang Y, Zhao LX, Jiang Y, Duan Y, Shen B. Ma M, et al. J Antibiot (Tokyo). 2017 Feb;70(2):200-203. doi: 10.1038/ja.2016.100. Epub 2016 Aug 10. J Antibiot (Tokyo). 2017. PMID: 27507632 No abstract available.
Comparative characterization of the lactimidomycin and iso-migrastatin biosynthetic machineries revealing unusual features for acyltransferase-less type I polyketide synthases and providing an opportunity to engineer new analogues.
Seo JW, Ma M, Kwong T, Ju J, Lim SK, Jiang H, Lohman JR, Yang C, Cleveland J, Zazopoulos E, Farnet CM, Shen B. Seo JW, et al. Among authors: ma m. Biochemistry. 2014 Dec 16;53(49):7854-65. doi: 10.1021/bi501396v. Epub 2014 Dec 1. Biochemistry. 2014. PMID: 25405956 Free PMC article.
8,066 results