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Camelid Ig V genes reveal significant human homology not seen in therapeutic target genes, providing for a powerful therapeutic antibody platform.
Klarenbeek A, El Mazouari K, Desmyter A, Blanchetot C, Hultberg A, de Jonge N, Roovers RC, Cambillau C, Spinelli S, Del-Favero J, Verrips T, de Haard HJ, Achour I. Klarenbeek A, et al. Among authors: de jonge n, de haard hj. MAbs. 2015;7(4):693-706. doi: 10.1080/19420862.2015.1046648. MAbs. 2015. PMID: 26018625 Free PMC article.
Structural Mimicry of Receptor Interaction by Antagonistic Interleukin-6 (IL-6) Antibodies.
Blanchetot C, De Jonge N, Desmyter A, Ongenae N, Hofman E, Klarenbeek A, Sadi A, Hultberg A, Kretz-Rommel A, Spinelli S, Loris R, Cambillau C, de Haard H. Blanchetot C, et al. Among authors: de jonge n, de haard h. J Biol Chem. 2016 Jun 24;291(26):13846-54. doi: 10.1074/jbc.M115.695528. Epub 2016 Apr 27. J Biol Chem. 2016. PMID: 27129274 Free PMC article.
Depleting MET-Expressing Tumor Cells by ADCC Provides a Therapeutic Advantage over Inhibiting HGF/MET Signaling.
Hultberg A, Morello V, Huyghe L, De Jonge N, Blanchetot C, Hanssens V, De Boeck G, Silence K, Festjens E, Heukers R, Roux B, Lamballe F, Ginestier C, Charafe-Jauffret E, Maina F, Brouckaert P, Saunders M, Thibault A, Dreier T, de Haard H, Michieli P. Hultberg A, et al. Among authors: de jonge n, de boeck g, de haard h. Cancer Res. 2015 Aug 15;75(16):3373-83. doi: 10.1158/0008-5472.CAN-15-0356. Epub 2015 Jul 3. Cancer Res. 2015. PMID: 26141862 Free article.
Four individually druggable MET hotspots mediate HGF-driven tumor progression.
Basilico C, Hultberg A, Blanchetot C, de Jonge N, Festjens E, Hanssens V, Osepa SI, De Boeck G, Mira A, Cazzanti M, Morello V, Dreier T, Saunders M, de Haard H, Michieli P. Basilico C, et al. Among authors: de jonge n, de boeck g, de haard h. J Clin Invest. 2014 Jul;124(7):3172-86. doi: 10.1172/JCI72316. Epub 2014 May 27. J Clin Invest. 2014. PMID: 24865428 Free PMC article.
VEGFR-1/Flt-1 inhibition increases angiogenesis and improves muscle function in a mouse model of Duchenne muscular dystrophy.
Bosco J, Zhou Z, Gabriëls S, Verma M, Liu N, Miller BK, Gu S, Lundberg DM, Huang Y, Brown E, Josiah S, Meiyappan M, Traylor MJ, Chen N, Asakura A, De Jonge N, Blanchetot C, de Haard H, Duffy HS, Keefe D. Bosco J, et al. Among authors: de jonge n, de haard h. Mol Ther Methods Clin Dev. 2021 Mar 23;21:369-381. doi: 10.1016/j.omtm.2021.03.013. eCollection 2021 Jun 11. Mol Ther Methods Clin Dev. 2021. PMID: 33898634 Free PMC article.
The NHance® Mutation-Equipped Anti-MET Antibody ARGX-111 Displays Increased Tissue Penetration and Anti-Tumor Activity in Advanced Cancer Patients.
Aftimos P, Rolfo C, Rottey S, Barthélémy P, Borg C, Park K, Oh DY, Kim SW, De Jonge N, Hanssens V, Zwanenpoel K, Molthoff C, Vugts D, Dreier T, Verheesen P, van Dongen GAMS, Jacobs J, Van Rompaey L, Hultberg A, Michieli P, Pauwels P, Fung S, Thibault A, de Haard H, Leupin N, Awada A. Aftimos P, et al. Among authors: de jonge n, de haard h. Biomedicines. 2021 Jun 10;9(6):665. doi: 10.3390/biomedicines9060665. Biomedicines. 2021. PMID: 34200749 Free PMC article.
Structural and thermodynamic characterization of Vibrio fischeri CcdB.
De Jonge N, Hohlweg W, Garcia-Pino A, Respondek M, Buts L, Haesaerts S, Lah J, Zangger K, Loris R. De Jonge N, et al. J Biol Chem. 2010 Feb 19;285(8):5606-13. doi: 10.1074/jbc.M109.068429. Epub 2009 Dec 2. J Biol Chem. 2010. PMID: 19959472 Free PMC article.
Driving forces of gyrase recognition by the addiction toxin CcdB.
Simic M, De Jonge N, Loris R, Vesnaver G, Lah J. Simic M, et al. Among authors: de jonge n. J Biol Chem. 2009 Jul 24;284(30):20002-10. doi: 10.1074/jbc.M109.014035. Epub 2009 May 22. J Biol Chem. 2009. PMID: 19465484 Free PMC article.
386 results