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Camelid Ig V genes reveal significant human homology not seen in therapeutic target genes, providing for a powerful therapeutic antibody platform.
Klarenbeek A, El Mazouari K, Desmyter A, Blanchetot C, Hultberg A, de Jonge N, Roovers RC, Cambillau C, Spinelli S, Del-Favero J, Verrips T, de Haard HJ, Achour I. Klarenbeek A, et al. Among authors: cambillau c. MAbs. 2015;7(4):693-706. doi: 10.1080/19420862.2015.1046648. MAbs. 2015. PMID: 26018625 Free PMC article.
Combining somatic mutations present in different in vivo affinity-matured antibodies isolated from immunized Lama glama yields ultra-potent antibody therapeutics.
Klarenbeek A, Blanchetot C, Schragel G, Sadi AS, Ongenae N, Hemrika W, Wijdenes J, Spinelli S, Desmyter A, Cambillau C, Hultberg A, Kretz-Rommel A, Dreier T, De Haard HJ, Roovers RC. Klarenbeek A, et al. Among authors: cambillau c. Protein Eng Des Sel. 2016 Apr;29(4):123-33. doi: 10.1093/protein/gzw003. Epub 2016 Mar 5. Protein Eng Des Sel. 2016. PMID: 26945588
Structural Mimicry of Receptor Interaction by Antagonistic Interleukin-6 (IL-6) Antibodies.
Blanchetot C, De Jonge N, Desmyter A, Ongenae N, Hofman E, Klarenbeek A, Sadi A, Hultberg A, Kretz-Rommel A, Spinelli S, Loris R, Cambillau C, de Haard H. Blanchetot C, et al. Among authors: cambillau c. J Biol Chem. 2016 Jun 24;291(26):13846-54. doi: 10.1074/jbc.M115.695528. Epub 2016 Apr 27. J Biol Chem. 2016. PMID: 27129274 Free PMC article.
Camelid nanobodies: killing two birds with one stone.
Desmyter A, Spinelli S, Roussel A, Cambillau C. Desmyter A, et al. Among authors: cambillau c. Curr Opin Struct Biol. 2015 Jun;32:1-8. doi: 10.1016/j.sbi.2015.01.001. Epub 2015 Jan 19. Curr Opin Struct Biol. 2015. PMID: 25614146 Review.
339 results