The antipyretic effect of paracetamol occurs independent of transient receptor potential ankyrin 1-mediated hypothermia and is associated with prostaglandin inhibition in the brain.
Mirrasekhian E, Nilsson JLÅ, Shionoya K, Blomgren A, Zygmunt PM, Engblom D, Högestätt ED, Blomqvist A.
Mirrasekhian E, et al. Among authors: blomgren a.
FASEB J. 2018 Oct;32(10):5751-5759. doi: 10.1096/fj.201800272R. Epub 2018 May 8.
FASEB J. 2018.
PMID: 29738273
Free article.
We conclude that paracetamol's antipyretic effect in mice is dependent on inhibition of cyclooxygenase activity, including the formation of pyrogenic prostaglandin E(2), whereas paracetamol-induced hypothermia likely is mediated by the activation of TRPA1 by electrophilic metabol …
We conclude that paracetamol's antipyretic effect in mice is dependent on inhibition of cyclooxygenase activity, including the formation of …