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An RNAi therapeutic targeting antithrombin to rebalance the coagulation system and promote hemostasis in hemophilia.
Sehgal A, Barros S, Ivanciu L, Cooley B, Qin J, Racie T, Hettinger J, Carioto M, Jiang Y, Brodsky J, Prabhala H, Zhang X, Attarwala H, Hutabarat R, Foster D, Milstein S, Charisse K, Kuchimanchi S, Maier MA, Nechev L, Kandasamy P, Kel'in AV, Nair JK, Rajeev KG, Manoharan M, Meyers R, Sorensen B, Simon AR, Dargaud Y, Negrier C, Camire RM, Akinc A. Sehgal A, et al. Among authors: prabhala h. Nat Med. 2015 May;21(5):492-7. doi: 10.1038/nm.3847. Epub 2015 Apr 13. Nat Med. 2015. PMID: 25849132
miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis.
Ma L, Young J, Prabhala H, Pan E, Mestdagh P, Muth D, Teruya-Feldstein J, Reinhardt F, Onder TT, Valastyan S, Westermann F, Speleman F, Vandesompele J, Weinberg RA. Ma L, et al. Among authors: prabhala h. Nat Cell Biol. 2010 Mar;12(3):247-56. doi: 10.1038/ncb2024. Epub 2010 Feb 21. Nat Cell Biol. 2010. PMID: 20173740 Free PMC article.
Concordance in Breast Cancer Grading by Artificial Intelligence on Whole Slide Images Compares With a Multi-Institutional Cohort of Breast Pathologists.
Mantrala S, Ginter PS, Mitkari A, Joshi S, Prabhala H, Ramachandra V, Kini L, Idress R, D'Alfonso TM, Fineberg S, Jaffer S, Sattar AK, Chagpar AB, Wilson P, Singh K, Harigopal M, Koka D. Mantrala S, et al. Among authors: prabhala h. Arch Pathol Lab Med. 2022 Nov 1;146(11):1369-1377. doi: 10.5858/arpa.2021-0299-OA. Arch Pathol Lab Med. 2022. PMID: 35271701 Free article.
Elevated IL-17 produced by TH17 cells promotes myeloma cell growth and inhibits immune function in multiple myeloma.
Prabhala RH, Pelluru D, Fulciniti M, Prabhala HK, Nanjappa P, Song W, Pai C, Amin S, Tai YT, Richardson PG, Ghobrial IM, Treon SP, Daley JF, Anderson KC, Kutok JL, Munshi NC. Prabhala RH, et al. Among authors: prabhala hk. Blood. 2010 Jul 1;115(26):5385-92. doi: 10.1182/blood-2009-10-246660. Epub 2010 Apr 15. Blood. 2010. PMID: 20395418 Free PMC article.
Supporting undergraduate research.
Ali F, Jadavji NM, Ong WC, Pandey KR, Patananan AN, Prabhala HK, Yang CH. Ali F, et al. Among authors: prabhala hk. Science. 2007 Jul 6;317(5834):42. doi: 10.1126/science.317.5834.42a. Science. 2007. PMID: 17615323 No abstract available.