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Report of the European Medicines Agency Conference on RNA-Based Medicines.
Ehmann F, Kuhn A, Pasmooij AMG, Humphreys A, Van Hengel A, Dooley B, Anliker B, Svensson C, Capaldi D, Henshall D, Cooke E, Zhou H, Bastaerts H, Smink J, Van Gerven J, Enes L, Nechev L, Hoefnagel M, Driessens M, Wenger M, Blanquie O, Widomski P, Herold R, Thürmer R, Ruiz S, Thirstrup S, Goody S, Zaks T, Cordò V, Aartsma-Rus AM. Ehmann F, et al. Among authors: nechev l. Nucleic Acid Ther. 2024 Feb;34(1):4-11. doi: 10.1089/nat.2023.0021. Epub 2024 Jan 4. Nucleic Acid Ther. 2024. PMID: 38174996
Convergent Biocatalytic Mediated Synthesis of siRNA.
Paul S, Gray D, Caswell J, Brooks J, Ye W, Moody TS, Radinov R, Nechev L. Paul S, et al. Among authors: nechev l. ACS Chem Biol. 2023 Oct 20;18(10):2183-2187. doi: 10.1021/acschembio.3c00071. Epub 2023 Apr 16. ACS Chem Biol. 2023. PMID: 37061926
An RNAi therapeutic targeting antithrombin to rebalance the coagulation system and promote hemostasis in hemophilia.
Sehgal A, Barros S, Ivanciu L, Cooley B, Qin J, Racie T, Hettinger J, Carioto M, Jiang Y, Brodsky J, Prabhala H, Zhang X, Attarwala H, Hutabarat R, Foster D, Milstein S, Charisse K, Kuchimanchi S, Maier MA, Nechev L, Kandasamy P, Kel'in AV, Nair JK, Rajeev KG, Manoharan M, Meyers R, Sorensen B, Simon AR, Dargaud Y, Negrier C, Camire RM, Akinc A. Sehgal A, et al. Among authors: nechev l. Nat Med. 2015 May;21(5):492-7. doi: 10.1038/nm.3847. Epub 2015 Apr 13. Nat Med. 2015. PMID: 25849132
Novel RNA interference-based therapies for sepsis.
Kosovrasti VY, Lukashev D, Nechev LV, Amiji MM. Kosovrasti VY, et al. Among authors: nechev lv. Expert Opin Biol Ther. 2014 Apr;14(4):419-35. doi: 10.1517/14712598.2014.875524. Epub 2014 Jan 8. Expert Opin Biol Ther. 2014. PMID: 24397825 Review.
Harnessing a physiologic mechanism for siRNA delivery with mimetic lipoprotein particles.
Nakayama T, Butler JS, Sehgal A, Severgnini M, Racie T, Sharman J, Ding F, Morskaya SS, Brodsky J, Tchangov L, Kosovrasti V, Meys M, Nechev L, Wang G, Peng CG, Fang Y, Maier M, Rajeev KG, Li R, Hettinger J, Barros S, Clausen V, Zhang X, Wang Q, Hutabarat R, Dokholyan NV, Wolfrum C, Manoharan M, Kotelianski V, Stoffel M, Sah DW. Nakayama T, et al. Among authors: nechev l. Mol Ther. 2012 Aug;20(8):1582-9. doi: 10.1038/mt.2012.33. Epub 2012 Jun 5. Mol Ther. 2012. PMID: 22850721 Free PMC article.
Widespread suppression of huntingtin with convection-enhanced delivery of siRNA.
Stiles DK, Zhang Z, Ge P, Nelson B, Grondin R, Ai Y, Hardy P, Nelson PT, Guzaev AP, Butt MT, Charisse K, Kosovrasti V, Tchangov L, Meys M, Maier M, Nechev L, Manoharan M, Kaemmerer WF, Gwost D, Stewart GR, Gash DM, Sah DW. Stiles DK, et al. Among authors: nechev l. Exp Neurol. 2012 Jan;233(1):463-71. doi: 10.1016/j.expneurol.2011.11.020. Epub 2011 Nov 19. Exp Neurol. 2012. PMID: 22119622
Unique gene-silencing and structural properties of 2'-fluoro-modified siRNAs.
Manoharan M, Akinc A, Pandey RK, Qin J, Hadwiger P, John M, Mills K, Charisse K, Maier MA, Nechev L, Greene EM, Pallan PS, Rozners E, Rajeev KG, Egli M. Manoharan M, et al. Among authors: nechev l. Angew Chem Int Ed Engl. 2011 Mar 1;50(10):2284-8. doi: 10.1002/anie.201006519. Epub 2011 Jan 31. Angew Chem Int Ed Engl. 2011. PMID: 21351337 Free PMC article. No abstract available.
42 results