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Novel antibacterial targets and compounds revealed by a high-throughput cell wall reporter assay.
J Bacteriol. 2015 May;197(10):1726-34. doi: 10.1128/JB.02552-14. Epub 2015 Mar 2.
J Bacteriol. 2015.
PMID: 25733621
Free PMC article.
Target-based resistance in Pseudomonas aeruginosa and Escherichia coli to NBTI 5463, a novel bacterial type II topoisomerase inhibitor.
Nayar AS, Dougherty TJ, Reck F, Thresher J, Gao N, Shapiro AB, Ehmann DE.
Nayar AS, et al.
Antimicrob Agents Chemother. 2015 Jan;59(1):331-7. doi: 10.1128/AAC.04077-14. Epub 2014 Oct 27.
Antimicrob Agents Chemother. 2015.
PMID: 25348539
Free PMC article.
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NBTI 5463 is a novel bacterial type II topoisomerase inhibitor with activity against gram-negative bacteria and in vivo efficacy.
Dougherty TJ, Nayar A, Newman JV, Hopkins S, Stone GG, Johnstone M, Shapiro AB, Cronin M, Reck F, Ehmann DE.
Dougherty TJ, et al.
Antimicrob Agents Chemother. 2014 May;58(5):2657-64. doi: 10.1128/AAC.02778-13. Epub 2014 Feb 24.
Antimicrob Agents Chemother. 2014.
PMID: 24566174
Free PMC article.
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Toward the rational design of carbapenem uptake in Pseudomonas aeruginosa.
Isabella VM, Campbell AJ, Manchester J, Sylvester M, Nayar AS, Ferguson KE, Tommasi R, Miller AA.
Isabella VM, et al. Among authors: nayar as.
Chem Biol. 2015 Apr 23;22(4):535-547. doi: 10.1016/j.chembiol.2015.03.018.
Chem Biol. 2015.
PMID: 25910245
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Thinking outside the "bug": a unique assay to measure intracellular drug penetration in gram-negative bacteria.
Zhou Y, Joubran C, Miller-Vedam L, Isabella V, Nayar A, Tentarelli S, Miller A.
Zhou Y, et al.
Anal Chem. 2015 Apr 7;87(7):3579-84. doi: 10.1021/ac504880r. Epub 2015 Mar 24.
Anal Chem. 2015.
PMID: 25753586
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Pharmacodynamic Profiling of a Siderophore-Conjugated Monocarbam in Pseudomonas aeruginosa: Assessing the Risk for Resistance and Attenuated Efficacy.
Kim A, Kutschke A, Ehmann DE, Patey SA, Crandon JL, Gorseth E, Miller AA, McLaughlin RE, Blinn CM, Chen A, Nayar AS, Dangel B, Tsai AS, Rooney MT, Murphy-Benenato KE, Eakin AE, Nicolau DP.
Kim A, et al. Among authors: nayar as.
Antimicrob Agents Chemother. 2015 Dec;59(12):7743-52. doi: 10.1128/AAC.00831-15. Epub 2015 Oct 5.
Antimicrob Agents Chemother. 2015.
PMID: 26438502
Free PMC article.
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FraG is necessary for filament integrity and heterocyst maturation in the cyanobacterium Anabaena sp. strain PCC 7120.
Nayar AS, Yamaura H, Rajagopalan R, Risser DD, Callahan SM.
Nayar AS, et al.
Microbiology (Reading). 2007 Feb;153(Pt 2):601-607. doi: 10.1099/mic.0.2006/002535-0.
Microbiology (Reading). 2007.
PMID: 17259632
Free article.
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