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Antagonistic cross-regulation between Sox9 and Sox10 controls an anti-tumorigenic program in melanoma.
Shakhova O, Cheng P, Mishra PJ, Zingg D, Schaefer SM, Debbache J, Häusel J, Matter C, Guo T, Davis S, Meltzer P, Mihic-Probst D, Moch H, Wegner M, Merlino G, Levesque MP, Dummer R, Santoro R, Cinelli P, Sommer L. Shakhova O, et al. Among authors: santoro r. PLoS Genet. 2015 Jan 28;11(1):e1004877. doi: 10.1371/journal.pgen.1004877. eCollection 2015 Jan. PLoS Genet. 2015. PMID: 25629959 Free PMC article.
The epigenetic modifier EZH2 controls melanoma growth and metastasis through silencing of distinct tumour suppressors.
Zingg D, Debbache J, Schaefer SM, Tuncer E, Frommel SC, Cheng P, Arenas-Ramirez N, Haeusel J, Zhang Y, Bonalli M, McCabe MT, Creasy CL, Levesque MP, Boyman O, Santoro R, Shakhova O, Dummer R, Sommer L. Zingg D, et al. Among authors: santoro r. Nat Commun. 2015 Jan 22;6:6051. doi: 10.1038/ncomms7051. Nat Commun. 2015. PMID: 25609585 Free article.
Methylation-dependent SOX9 expression mediates invasion in human melanoma cells and is a negative prognostic factor in advanced melanoma.
Cheng PF, Shakhova O, Widmer DS, Eichhoff OM, Zingg D, Frommel SC, Belloni B, Raaijmakers MI, Goldinger SM, Santoro R, Hemmi S, Sommer L, Dummer R, Levesque MP. Cheng PF, et al. Among authors: santoro r. Genome Biol. 2015 Feb 22;16(1):42. doi: 10.1186/s13059-015-0594-4. Genome Biol. 2015. PMID: 25885555 Free PMC article.
EZH2-Mediated Primary Cilium Deconstruction Drives Metastatic Melanoma Formation.
Zingg D, Debbache J, Peña-Hernández R, Antunes AT, Schaefer SM, Cheng PF, Zimmerli D, Haeusel J, Calçada RR, Tuncer E, Zhang Y, Bossart R, Wong KK, Basler K, Dummer R, Santoro R, Levesque MP, Sommer L. Zingg D, et al. Among authors: santoro r. Cancer Cell. 2018 Jul 9;34(1):69-84.e14. doi: 10.1016/j.ccell.2018.06.001. Epub 2018 Jun 28. Cancer Cell. 2018. PMID: 30008323 Free article.
Epigenetic control of melanoma cell invasiveness by the stem cell factor SALL4.
Diener J, Baggiolini A, Pernebrink M, Dalcher D, Lerra L, Cheng PF, Varum S, Häusel J, Stierli S, Treier M, Studer L, Basler K, Levesque MP, Dummer R, Santoro R, Cantù C, Sommer L. Diener J, et al. Among authors: santoro r. Nat Commun. 2021 Aug 20;12(1):5056. doi: 10.1038/s41467-021-25326-8. Nat Commun. 2021. PMID: 34417458 Free PMC article.
PRAMEL7 and CUL2 decrease NuRD stability to establish ground-state pluripotency.
Rupasinghe M, Bersaglieri C, Leslie Pedrioli DM, Pedrioli PG, Panatta M, Hottiger MO, Cinelli P, Santoro R. Rupasinghe M, et al. Among authors: santoro r. EMBO Rep. 2024 Mar;25(3):1453-1468. doi: 10.1038/s44319-024-00083-z. Epub 2024 Feb 8. EMBO Rep. 2024. PMID: 38332149 Free PMC article.
BAZ2A (TIP5) is involved in epigenetic alterations in prostate cancer and its overexpression predicts disease recurrence.
Gu L, Frommel SC, Oakes CC, Simon R, Grupp K, Gerig CY, Bär D, Robinson MD, Baer C, Weiss M, Gu Z, Schapira M, Kuner R, Sültmann H, Provenzano M; ICGC Project on Early Onset Prostate Cancer; Yaspo ML, Brors B, Korbel J, Schlomm T, Sauter G, Eils R, Plass C, Santoro R. Gu L, et al. Among authors: santoro r. Nat Genet. 2015 Jan;47(1):22-30. doi: 10.1038/ng.3165. Epub 2014 Dec 8. Nat Genet. 2015. PMID: 25485837
Pramel7 mediates ground-state pluripotency through proteasomal-epigenetic combined pathways.
Graf U, Casanova EA, Wyck S, Dalcher D, Gatti M, Vollenweider E, Okoniewski MJ, Weber FA, Patel SS, Schmid MW, Li J, Sharif J, Wanner GA, Koseki H, Wong J, Pelczar P, Penengo L, Santoro R, Cinelli P. Graf U, et al. Among authors: santoro r. Nat Cell Biol. 2017 Jul;19(7):763-773. doi: 10.1038/ncb3554. Epub 2017 Jun 12. Nat Cell Biol. 2017. PMID: 28604677
588 results