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Acquired tumor cell resistance to sunitinib causes resistance in a HT-29 human colon cancer xenograft mouse model without affecting sunitinib biodistribution or the tumor microvasculature.
Oncoscience. 2014 Dec 15;1(12):844-53. doi: 10.18632/oncoscience.106. eCollection 2014.
Oncoscience. 2014.
PMID: 25621299
Free PMC article.
Lysosomal sequestration of sunitinib: a novel mechanism of drug resistance.
Gotink KJ, Broxterman HJ, Labots M, de Haas RR, Dekker H, Honeywell RJ, Rudek MA, Beerepoot LV, Musters RJ, Jansen G, Griffioen AW, Assaraf YG, Pili R, Peters GJ, Verheul HM.
Gotink KJ, et al.
Clin Cancer Res. 2011 Dec 1;17(23):7337-46. doi: 10.1158/1078-0432.CCR-11-1667. Epub 2011 Oct 6.
Clin Cancer Res. 2011.
PMID: 21980135
Free PMC article.
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Understanding the causes of multidrug resistance in cancer: a comparison of doxorubicin and sunitinib.
Broxterman HJ, Gotink KJ, Verheul HM.
Broxterman HJ, et al. Among authors: gotink kj.
Drug Resist Updat. 2009 Aug-Oct;12(4-5):114-26. doi: 10.1016/j.drup.2009.07.001. Epub 2009 Aug 3.
Drug Resist Updat. 2009.
PMID: 19648052
Review.
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Anti-angiogenic tyrosine kinase inhibitors: what is their mechanism of action?
Gotink KJ, Verheul HM.
Gotink KJ, et al.
Angiogenesis. 2010 Mar;13(1):1-14. doi: 10.1007/s10456-009-9160-6. Epub 2009 Dec 11.
Angiogenesis. 2010.
PMID: 20012482
Free PMC article.
Review.
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Cross-resistance to clinically used tyrosine kinase inhibitors sunitinib, sorafenib and pazopanib.
Gotink KJ, Rovithi M, de Haas RR, Honeywell RJ, Dekker H, Poel D, Azijli K, Peters GJ, Broxterman HJ, Verheul HM.
Gotink KJ, et al.
Cell Oncol (Dordr). 2015 Apr;38(2):119-29. doi: 10.1007/s13402-015-0218-8. Epub 2015 Feb 11.
Cell Oncol (Dordr). 2015.
PMID: 25665527
Free PMC article.
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The Potential Role of Lysosomal Sequestration in Sunitinib Resistance of Renal Cell Cancer.
Azijli K, Gotink KJ, Verheul HM.
Azijli K, et al. Among authors: gotink kj.
J Kidney Cancer VHL. 2015 Jan 21;2(4):195-203. doi: 10.15586/jkcvhl.2015.44. eCollection 2015.
J Kidney Cancer VHL. 2015.
PMID: 28326274
Free PMC article.
Review.
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Evaluation of a tyrosine kinase peptide microarray for tyrosine kinase inhibitor therapy selection in cancer.
Labots M, Gotink KJ, Dekker H, Azijli K, van der Mijn JC, Huijts CM, Piersma SR, Jiménez CR, Verheul HM.
Labots M, et al. Among authors: gotink kj.
Exp Mol Med. 2016 Dec 16;48(12):e279. doi: 10.1038/emm.2016.114.
Exp Mol Med. 2016.
PMID: 27980342
Free PMC article.
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