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Palmitoleic acid (n-7) increases white adipocyte lipolysis and lipase content in a PPARα-dependent manner.
Bolsoni-Lopes A, Festuccia WT, Farias TS, Chimin P, Torres-Leal FL, Derogis PB, de Andrade PB, Miyamoto S, Lima FB, Curi R, Alonso-Vale MI. Bolsoni-Lopes A, et al. Among authors: chimin p. Am J Physiol Endocrinol Metab. 2013 Nov 1;305(9):E1093-102. doi: 10.1152/ajpendo.00082.2013. Epub 2013 Sep 10. Am J Physiol Endocrinol Metab. 2013. PMID: 24022867 Free article.
PPARγ activation attenuates glucose intolerance induced by mTOR inhibition with rapamycin in rats.
Festuccia WT, Blanchard PG, Belchior T, Chimin P, Paschoal VA, Magdalon J, Hirabara SM, Simões D, St-Pierre P, Carpinelli A, Marette A, Deshaies Y. Festuccia WT, et al. Among authors: chimin p. Am J Physiol Endocrinol Metab. 2014 May 1;306(9):E1046-54. doi: 10.1152/ajpendo.00683.2013. Epub 2014 Mar 11. Am J Physiol Endocrinol Metab. 2014. PMID: 24619883 Free article.
Pinealectomy interferes with the circadian clock genes expression in white adipose tissue.
de Farias Tda S, de Oliveira AC, Andreotti S, do Amaral FG, Chimin P, de Proença AR, Leal FL, Sertié RA, Campana AB, Lopes AB, de Souza AH, Cipolla-Neto J, Lima FB. de Farias Tda S, et al. Among authors: chimin p. J Pineal Res. 2015 Apr;58(3):251-61. doi: 10.1111/jpi.12211. Epub 2015 Feb 20. J Pineal Res. 2015. PMID: 25626464
mTORC1 inhibition with rapamycin exacerbates adipose tissue inflammation in obese mice and dissociates macrophage phenotype from function.
Paschoal VA, Amano MT, Belchior T, Magdalon J, Chimin P, Andrade ML, Ortiz-Silva M, Castro É, Yamashita AS, Rosa Neto JC, Câmara NO, Festuccia WT. Paschoal VA, et al. Among authors: chimin p. Immunobiology. 2017 Feb;222(2):261-271. doi: 10.1016/j.imbio.2016.09.014. Epub 2016 Sep 28. Immunobiology. 2017. PMID: 27692982
Adipocyte mTORC1 deficiency promotes adipose tissue inflammation and NLRP3 inflammasome activation via oxidative stress and de novo ceramide synthesis.
Chimin P, Andrade ML, Belchior T, Paschoal VA, Magdalon J, Yamashita AS, Castro É, Castoldi A, Chaves-Filho AB, Yoshinaga MY, Miyamoto S, Câmara NO, Festuccia WT. Chimin P, et al. J Lipid Res. 2017 Sep;58(9):1797-1807. doi: 10.1194/jlr.M074518. Epub 2017 Jul 5. J Lipid Res. 2017. PMID: 28679588 Free PMC article.
Adipocyte-specific mTORC2 deficiency impairs BAT and iWAT thermogenic capacity without affecting glucose uptake and energy expenditure in cold-acclimated mice.
Castro É, Vieira TS, Oliveira TE, Ortiz-Silva M, Andrade ML, Tomazelli CA, Peixoto AS, Sobrinho CR, Moreno MF, Gilio GR, Moreira RJ, Guimarães RC, Perandini LA, Chimin P, Reckziegel P, Moretti EH, Steiner AA, Laplante M, Festuccia WT. Castro É, et al. Among authors: chimin p. Am J Physiol Endocrinol Metab. 2021 Nov 1;321(5):E592-E605. doi: 10.1152/ajpendo.00587.2020. Epub 2021 Sep 20. Am J Physiol Endocrinol Metab. 2021. PMID: 34541875 Free article.
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