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Brusatol provokes a rapid and transient inhibition of Nrf2 signaling and sensitizes mammalian cells to chemical toxicity-implications for therapeutic targeting of Nrf2.
Olayanju A, Copple IM, Bryan HK, Edge GT, Sison RL, Wong MW, Lai ZQ, Lin ZX, Dunn K, Sanderson CM, Alghanem AF, Cross MJ, Ellis EC, Ingelman-Sundberg M, Malik HZ, Kitteringham NR, Goldring CE, Park BK. Olayanju A, et al. Among authors: lin zx. Free Radic Biol Med. 2015 Jan;78:202-12. doi: 10.1016/j.freeradbiomed.2014.11.003. Epub 2014 Nov 14. Free Radic Biol Med. 2015. PMID: 25445704 Free PMC article.
The Nrf2 inhibitor brusatol is a potent antitumour agent in an orthotopic mouse model of colorectal cancer.
Evans JP, Winiarski BK, Sutton PA, Jones RP, Ressel L, Duckworth CA, Pritchard DM, Lin ZX, Fretwell VL, Tweedle EM, Costello E, Goldring CE, Copple IM, Park BK, Palmer DH, Kitteringham NR. Evans JP, et al. Among authors: lin zx. Oncotarget. 2018 Jun 5;9(43):27104-27116. doi: 10.18632/oncotarget.25497. eCollection 2018 Jun 5. Oncotarget. 2018. PMID: 29930754 Free PMC article.
443 results