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Brusatol provokes a rapid and transient inhibition of Nrf2 signaling and sensitizes mammalian cells to chemical toxicity-implications for therapeutic targeting of Nrf2.
Free Radic Biol Med. 2015 Jan;78:202-12. doi: 10.1016/j.freeradbiomed.2014.11.003. Epub 2014 Nov 14.
Free Radic Biol Med. 2015.
PMID: 25445704
Free PMC article.
Evidence for metabolic cleavage of a PEGylated protein in vivo using multiple analytical methodologies.
Elliott VL, Edge GT, Phelan MM, Lian LY, Webster R, Finn RF, Park BK, Kitteringham NR.
Elliott VL, et al. Among authors: edge gt.
Mol Pharm. 2012 May 7;9(5):1291-301. doi: 10.1021/mp200587m. Epub 2012 Apr 18.
Mol Pharm. 2012.
PMID: 22480236
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