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Brusatol provokes a rapid and transient inhibition of Nrf2 signaling and sensitizes mammalian cells to chemical toxicity-implications for therapeutic targeting of Nrf2.
Olayanju A, Copple IM, Bryan HK, Edge GT, Sison RL, Wong MW, Lai ZQ, Lin ZX, Dunn K, Sanderson CM, Alghanem AF, Cross MJ, Ellis EC, Ingelman-Sundberg M, Malik HZ, Kitteringham NR, Goldring CE, Park BK. Olayanju A, et al. Among authors: cross mj. Free Radic Biol Med. 2015 Jan;78:202-12. doi: 10.1016/j.freeradbiomed.2014.11.003. Epub 2014 Nov 14. Free Radic Biol Med. 2015. PMID: 25445704 Free PMC article.
Human pluripotent stem cells for modeling toxicity.
Sison-Young RL, Kia R, Heslop J, Kelly L, Rowe C, Cross MJ, Kitteringham NR, Hanley N, Park BK, Goldring CE. Sison-Young RL, et al. Among authors: cross mj. Adv Pharmacol. 2012;63:207-56. doi: 10.1016/B978-0-12-398339-8.00006-9. Adv Pharmacol. 2012. PMID: 22776643 Review.
ERK5: structure, regulation and function.
Nithianandarajah-Jones GN, Wilm B, Goldring CE, Müller J, Cross MJ. Nithianandarajah-Jones GN, et al. Among authors: cross mj. Cell Signal. 2012 Nov;24(11):2187-96. doi: 10.1016/j.cellsig.2012.07.007. Epub 2012 Jul 16. Cell Signal. 2012. PMID: 22800864 Review.
Safety pharmacology--current and emerging concepts.
Hamdam J, Sethu S, Smith T, Alfirevic A, Alhaidari M, Atkinson J, Ayala M, Box H, Cross M, Delaunois A, Dermody A, Govindappa K, Guillon JM, Jenkins R, Kenna G, Lemmer B, Meecham K, Olayanju A, Pestel S, Rothfuss A, Sidaway J, Sison-Young R, Smith E, Stebbings R, Tingle Y, Valentin JP, Williams A, Williams D, Park K, Goldring C. Hamdam J, et al. Toxicol Appl Pharmacol. 2013 Dec 1;273(2):229-41. doi: 10.1016/j.taap.2013.04.039. Epub 2013 Jun 1. Toxicol Appl Pharmacol. 2013. PMID: 23732082 Review.
The role of ERK5 in endothelial cell function.
Nithianandarajah-Jones GN, Wilm B, Goldring CE, Müller J, Cross MJ. Nithianandarajah-Jones GN, et al. Among authors: cross mj. Biochem Soc Trans. 2014 Dec;42(6):1584-9. doi: 10.1042/BST20140276. Biochem Soc Trans. 2014. PMID: 25399574
Failure to upregulate cell surface PD-1 is associated with dysregulated stimulation of T cells by TGN1412-like CD28 superagonist.
Thaventhiran T, Alhumeed N, Yeang HX, Sethu S, Downey JS, Alghanem AF, Olayanju A, Smith EL, Cross MJ, Webb SD, Williams DP, Bristow A, Ball C, Stebbings R, Sathish JG. Thaventhiran T, et al. Among authors: cross mj. MAbs. 2014;6(5):1290-9. doi: 10.4161/mabs.29758. Epub 2014 Oct 30. MAbs. 2014. PMID: 25517314 Free PMC article.
Concise review: workshop review: understanding and assessing the risks of stem cell-based therapies.
Heslop JA, Hammond TG, Santeramo I, Tort Piella A, Hopp I, Zhou J, Baty R, Graziano EI, Proto Marco B, Caron A, Sköld P, Andrews PW, Baxter MA, Hay DC, Hamdam J, Sharpe ME, Patel S, Jones DR, Reinhardt J, Danen EH, Ben-David U, Stacey G, Björquist P, Piner J, Mills J, Rowe C, Pellegrini G, Sethu S, Antoine DJ, Cross MJ, Murray P, Williams DP, Kitteringham NR, Goldring CE, Park BK. Heslop JA, et al. Among authors: cross mj. Stem Cells Transl Med. 2015 Apr;4(4):389-400. doi: 10.5966/sctm.2014-0110. Epub 2015 Feb 26. Stem Cells Transl Med. 2015. PMID: 25722427 Free PMC article. Review.
Innovative organotypic in vitro models for safety assessment: aligning with regulatory requirements and understanding models of the heart, skin, and liver as paradigms.
Pridgeon CS, Schlott C, Wong MW, Heringa MB, Heckel T, Leedale J, Launay L, Gryshkova V, Przyborski S, Bearon RN, Wilkinson EL, Ansari T, Greenman J, Hendriks DFG, Gibbs S, Sidaway J, Sison-Young RL, Walker P, Cross MJ, Park BK, Goldring CEP. Pridgeon CS, et al. Among authors: cross mj. Arch Toxicol. 2018 Feb;92(2):557-569. doi: 10.1007/s00204-018-2152-9. Epub 2018 Jan 23. Arch Toxicol. 2018. PMID: 29362863 Free PMC article. Review.
168 results